oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Collagen Gentamicin for Prevention of Sternal Wound Infection: Effective or Not?
Orebro University Hospital. Dept Cardiovasc & Thorac Surg.
Karolinska Inst, Inst Environm Med, Unit Intervent & Implementat Res, S-10401 Stockholm, Sweden..
2013 (English)In: The thoracic and cardiovascular surgeon, ISSN 0171-6425, E-ISSN 1439-1902, Vol. 61, no 3, 185-193 p.Article in journal (Refereed) Published
Abstract [en]

Background Prophylactic local application of collagen-gentamicin sponges for prevention of sternal wound infections (SWI) after cardiac surgery has been used routinely in risk patients for several years at our center. However, a recent US study failed to show a significant reduction in SWI with the prophylaxis. Therefore, a systematic reevaluation of the effect of local collagen gentamicin was conducted. Methods A complete follow-up of all cardiac surgery patients 2 months postoperatively was achieved. All SWIs were recorded. The effect of the prophylaxis was analyzed, and differences in risk factors were compensated for using multiple logistic regression analyses and Coarsened Exact Matching (CEM). Results A total of 950 patients were included. Established risk factors for SWI were confirmed. The use of collagen-gentamicin prophylaxis was independently associated with a highly significant reduction in SWI (odds ratio [OR] 0.30, 95% confidence interval 0.16 to 0.57; p < 0.001). Applying the more advanced statistical method, CEM indicated that the effect of the prophylaxis may be even greater. Conclusions The use of local collagen-gentamicin prophylaxis was associated with an approximately 70% reduction in the rate of SWI compared with standard intravenous antibiotic prophylaxis alone.

Place, publisher, year, edition, pages
2013. Vol. 61, no 3, 185-193 p.
Keyword [en]
wound infection, statistics, wound healing, surgery, complications
National Category
Cardiac and Cardiovascular Systems Surgery
Identifiers
URN: urn:nbn:se:oru:diva-56530DOI: 10.1055/s-0032-1322626ISI: 000317175800003PubMedID: 23081834OAI: oai:DiVA.org:oru-56530DiVA: diva2:1082666
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-03-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Friberg, Örjan
By organisation
Orebro University Hospital
In the same journal
The thoracic and cardiovascular surgeon
Cardiac and Cardiovascular SystemsSurgery

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf