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Gene therapy clinical trials worldwide to 2012 an update
Childrens Med Res Inst, Gene Therapy Res Unit, Westmead, NSW, Australia.;Childrens Hosp, Westmead, NSW, Australia.;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia..
Childrens Med Res Inst, Gene Therapy Res Unit, Westmead, NSW, Australia.;Childrens Hosp, Westmead, NSW, Australia.;Univ Sydney, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia..
Imperial Healthcare NHS Trust, London, England..
Örebro University Hospital. Dept Lab Med.
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2013 (English)In: Journal of Gene Medicine, ISSN 1099-498X, E-ISSN 1521-2254, Vol. 15, no 2, 65-77 p.Article, review/survey (Refereed) Published
Abstract [en]

To date, over 1800 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. Our database brings together global information on gene therapy clinical trials from official agency sources, published literature, conference presentations and posters kindly provided to us by individual investigators or trial sponsors. This review presents our analysis of clinical trials that, to the best of our knowledge, have been or are being performed worldwide. As of our June 2012 update, we have entries on 1843 trials undertaken in 31 countries. We have analysed the geographical distribution of trials, the disease indications (or other reasons) for trials, the proportions to which different vector types are used, and which genes have been transferred. Details of the analyses presented, and our searchable database are available on The Journal of Gene Medicine Gene Therapy Clinical Trials Worldwide website at: http://www.wiley.co.uk/genmed/clinical. We also provide an overview of the progress being made in clinical trials of gene therapy approaches around the world and discuss the prospects for the future. Copyright (c) 2013 John Wiley & Sons, Ltd.

Place, publisher, year, edition, pages
2013. Vol. 15, no 2, 65-77 p.
Keyword [en]
clinical trials, gene therapy, The Journal of Gene Medicine, worldwide, database
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:oru:diva-56545DOI: 10.1002/jgm.2698ISI: 000315494400002PubMedID: 23355455OAI: oai:DiVA.org:oru-56545DiVA: diva2:1082702
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-11-29Bibliographically approved

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