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Preoperative NT-proBNP independently predicts outcome in patients with acute coronary syndrome undergoing CABG
Dept Cardiothorac Surg & Anaesthesia, Linköping Univ, Linköping Univ Hosp, Linköping, Sweden..
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Dept Cardiothorac Surg & Cardiothorac Anesthesia, Örebro University Hospital, Örebro, Sweden.
Dept Cardiothorac Surg & Anaesthesia, Linköping Univ, Linköping Univ Hosp, Linköping, Sweden..
Dept Cardiothorac Surg & Anaesthesia, Linköping Univ, Linköping Univ Hosp, Linköping, Sweden.Örebro University Hospital, Örebro, Sweden.
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2013 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 47, no 1, p. 28-35Article in journal (Refereed) Published
Abstract [en]

Objectives. The predictive value of preoperative N-terminal pro-B-type natriuretic peptide (NT-proBNP) was evaluated in patients with acute coronary syndrome undergoing coronary artery bypass grafting (CABG). Design. As a substudy to a clinical trial 383 patients with acute coronary syndrome undergoing CABG were studied. 17 patients had a concomitant procedure. NT-proBNP was measured immediately preoperatively and evaluated with regard to in-hospital mortality, and severe circulatory failure postoperatively according to prespecified criteria. Follow-up was 3.2 +/- 0.9 years. Results. In patients with isolated CABG, receiver operating characteristics (ROC) analysis showed an area under the curve (AUC) of 0.82 for in-hospital mortality and 0.87 for severe circulatory failure respectively with a best cut-off for preoperative NT-proBNP of 1028 ng/L. This cut-off level independently predicted severe circulatory failure. Patients with NT-proBNP < 1028 ng/L had significantly better long-term survival (p = 0.004). Preoperative NT-proBNP was higher in patients with concomitant procedure than isolated CABG (2146 +/- 1858 v 887 +/- 1635 ng/L; p = 0.0005). In patients with concomitant procedure ROC analysis showed an AUC of 0.93 for severe circulatory failure with a best cut-off for preoperative NT-proBNP of 3145 ng/L. Conclusions. Preoperative NT-proBNP predicted in-hospital mortality, severe circulatory failure postoperatively and long-term survival in patients undergoing surgery for acute coronary syndrome but a higher threshold was found in patients having concomitant procedures.

Place, publisher, year, edition, pages
2013. Vol. 47, no 1, p. 28-35
Keyword [en]
acute coronary syndrome, coronary artery bypass grafting, natriuretic peptides
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-56564DOI: 10.3109/14017431.2012.731518ISI: 000313678500004PubMedID: 22989031OAI: oai:DiVA.org:oru-56564DiVA, id: diva2:1082791
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2018-04-16Bibliographically approved

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Vidlund, Mårten

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