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Target Gene Sequencing To Define the Susceptibility of Neisseria meningitidis to Ciprofloxacin
Inst Pasteur, Invas Bacterial Infect Unit, Paris, France.;Natl Reference Ctr Meningococci, Paris, France..
Orebro University Hospital. Dept Lab Med, Natl Reference Lab Pathogen Neisseria, Orebro, Sweden..
Inst Hlth Carlos III, Reference Lab Meningococci, Madrid, Spain..ORCID iD: 0000-0002-8339-0950
Ist Super Sanita, Dept Infect Parasites & Immune Mediated Dis, I-00161 Rome, Italy..
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2013 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 57, no 4, 1961-1964 p.Article in journal (Refereed) Published
Abstract [en]

Meningococcal gyrA gene sequence data, MICs, and mouse infection were used to define the ciprofloxacin breakpoint for Neisseria meningitidis. Residue T91 or D95 of GyrA was altered in all meningococcal isolates with MICs of >= 0.064 mu g/ml but not among isolates with MICs of <= 0.032 mu g/ml. Experimental infection of ciprofloxacin-treated mice showed slower bacterial clearance when GyrA was altered. These data suggest a MIC of >= 0.064 mu g/ml as the ciprofloxacin breakpoint for meningococci and argue for the molecular detection of ciprofloxacin resistance.

Place, publisher, year, edition, pages
2013. Vol. 57, no 4, 1961-1964 p.
National Category
Medical Genetics
Identifiers
URN: urn:nbn:se:oru:diva-56565DOI: 10.1128/AAC.02184-12ISI: 000316119100060PubMedID: 23357770OAI: oai:DiVA.org:oru-56565DiVA: diva2:1082792
Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2017-03-17Bibliographically approved

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Thulin Hedberg, SaraAbad, RaquelJolley, Keith A.Stefanelli, PaolaUnemo, Magnus
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