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Risk of cutaneous malignant melanoma in patients with celiac disease: A population-based study
Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA; Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Oncology-Pathology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Department of Oncology-Pathology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA.
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2014 (English)In: The Journal of American Academy of Dermatology, ISSN 0190-9622, E-ISSN 1097-6787, Vol. 71, no 2, 245-248 p.Article in journal (Refereed) Published
Abstract [en]

Background: Celiac disease (CD) carries an increased risk of several malignancies, including cancers of the gastrointestinal tract and hematologic malignancies. The disease course of cutaneous malignant melanoma (CMM) is affected by the immune status of the host, and therefore may be associated with CD.

Objective: We sought to test for an association between CD and CMM in a population-based setting.

Methods: We queried all (n = 28) pathology departments in Sweden and identified patients with intestinal histology consistent with CD. Each patient was matched to up to 5 control subjects by age, gender, calendar period, and region. Using Cox proportional hazards, we tested for an association between CD and the subsequent diagnosis of CMM.

Results: Among patients with CD (n = 29,028), 78 subsequently developed CMM (0.3%). Compared with control subjects there was no significant association between CD and CMM (hazard ratio 0.94, 95% confidence interval 0.73-1.20). This null association was similar for men (hazard ratio 0.99, 95% confidence interval 0.68-1.44) and women (hazard ratio 0.89, 95% confidence interval 0.64-1.24), and in all age strata.

Limitations: Lack of data regarding undiagnosed CD is a limitation.

Conclusion: In this population-based study we found no association between CD and the subsequent diagnosis of CMM. Prior studies showing a positive association between these 2 entities may have been a result of referral bias.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 71, no 2, 245-248 p.
Keyword [en]
celiac disease, melanoma
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-56570DOI: 10.1016/j.jaad.2014.03.029ISI: 000339997700019PubMedID: 24792481Scopus ID: 2-s2.0-84904724105OAI: oai:DiVA.org:oru-56570DiVA: diva2:1082917
Funder
Swedish Cancer SocietySwedish Society of MedicineSwedish Research Council, 522-2A09-195
Note

Funding Agencies:

American-Scandinavian Foundation

Celiac Sprue Association

National Center for Advancing Translational Sciences, National Institutes of Health  UL1 TR000040

Radiumhemmet Research Funds

Stockholm County Council

Örebro University Hospital

Karolinska Institutet

Swedish Celiac Society

Available from: 2017-03-20 Created: 2017-03-20 Last updated: 2017-11-29Bibliographically approved

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