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Isotretinoin Use and Celiac Disease: A Population-Based Cross-Sectional Study
Columbia Univ, Coll Phys & Surg, Dept Med, Celiac Dis Ctr, New York, NY USA.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden..
Karolinska Inst, Clin Epidemiol Unit, Stockholm, Sweden..
Univ Chicago, Celiac Dis Ctr, Chicago, IL 60637 USA..
Univ Chicago, Celiac Dis Ctr, Chicago, IL 60637 USA..
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2014 (English)In: American Journal of Clinical Dermatology, ISSN 1175-0561, E-ISSN 1179-1888, Vol. 15, no 6, 537-542 p.Article in journal (Refereed) Published
Abstract [en]

Background and aim: Isotretinoin, a vitamin A analogue, can promote a pro-inflammatory milieu in the small intestine in response to dietary antigens. We hypothesized that oral isotretinoin exposure would increase the risk of celiac disease (CD).

Methods: We contacted all 28 pathology departments in Sweden, and through biopsy reports identified 26,739 individuals with CD. We then compared the prevalence of ever using oral isotretinoin to the prevalence in 134,277 matched controls through conditional logistic regression. Data on isotretinoin exposure were obtained from the national Swedish Prescribed Drug Registry. As the only indication for isotretinoin use in Sweden is acne, we also examined its relationship to CD. Data on acne were obtained from the Swedish Patient Registry.

Results: Ninety-three individuals with CD (0.35 %) and 378 matched controls (0.28 %) had a prescription of isotretinoin. This corresponded to an odds ratio (OR) of 1.22 [95 % confidence interval (CI) 0.97-1.54]. Risk estimates were similar in men and women, and when we restricted our data to individuals diagnosed after the start of the Prescribed Drug Registry. Restricting our analyses to individuals diagnosed aged 12-45 years did not influence the risk estimates (OR 1.38, 95 % CI 0.97-1.97). Meanwhile, having a diagnosis of acne was positively associated with CD (OR 1.34, 95 % CI 1.20-1.51).

Conclusions: This study found no association between isotretinoin use and CD, but a small excess risk of CD in patients with a diagnosis of acne.

Place, publisher, year, edition, pages
Springer, 2014. Vol. 15, no 6, 537-542 p.
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-56580DOI: 10.1007/s40257-014-0090-8ISI: 000345386500007PubMedID: 25022269ScopusID: 2-s2.0-84911960137OAI: oai:DiVA.org:oru-56580DiVA: diva2:1083002
Available from: 2017-03-20 Created: 2017-03-20 Last updated: 2017-03-20Bibliographically approved

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