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Smoking, use of moist snuff and risk of celiac disease: a prospective study
Orebro University Hospital. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden.ORCID iD: 0000-0003-1024-5602
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-5112-8894
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
2014 (English)In: BMC Gastroenterology, ISSN 1471-230X, E-ISSN 1471-230X, Vol. 14, 120Article in journal (Refereed) Published
Abstract [en]

Background: Smoking status has been linked to several chronic inflammatory conditions but earlier research on smoking and celiac disease (CD) is contradictive. There are little data on moist snuff use and CD. The purpose of this study was to investigate the association between smoking, moist snuff use and later CD.

Methods: We identified individuals with biopsy-verified CD (villous atrophy, histopathology stage Marsh III) through biopsy-reports from Sweden's 28 pathology departments. Data on smoking and moist snuff were collected from the Swedish construction worker database "Bygghalsan" that includes preventive health care check-up data. Through poisson regression we calculated relative risks (RRs) for later CD according to smoking status (n = 305,722), and moist snuff status (n = 199,200) adjusting for age, sex and decade.

Results: During follow-up 488 individuals with smoking data, and 310 with moist snuff data had a diagnosis of CD. The risk of CD was independent of smoking status with all RRs being statistically insignificant and ranging between 0.9 and 1.0. Compared to non-smokers, neither current smokers (RR = 0.93; 95% CI = 0.76-1.14) nor ex-smokers (RR = 0.98; 95% CI = 0.75-1.28) were at increased or decreased risk of CD. Risk estimates were similar in moderate smokers (RR = 0.92; 0.72-1.16) and heavy smokers (RR = 0.95; 0.74-1.24), and did not change when we examined the risk more than ten years after health examination (RR-moderate: 0.90; and RR-heavy: 0.95; both p > 0.05). Moist snuff use was not associated with later CD (RR = 1.00; 0.78-1.28), or with CD after more than ten years of follow-up (RR = 1.05; 0.80-1.38).

Conclusions: We found no association between smoking, moist snuff use and future CD.

Place, publisher, year, edition, pages
BioMed Central, 2014. Vol. 14, 120
Keyword [en]
Autoimmune, Coeliac, Gluten, Smoking, Moist snuff, Snus
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-56614DOI: 10.1186/1471-230X-14-120ISI: 000338583300003PubMedID: 24994113Scopus ID: 2-s2.0-84904415140OAI: oai:DiVA.org:oru-56614DiVA: diva2:1083328
Funder
Swedish Research Council
Available from: 2017-03-21 Created: 2017-03-21 Last updated: 2017-03-21Bibliographically approved

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