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Does hemochromatosis predispose to celiac disease?: A study of 29,096 celiac disease patients
Örebro University Hospital. Dept Paediat, Örebro University Hospital, Örebro, Sweden; Dept Med, Clin Epidemiol Unit, Karolinska Instute, Stockholm, Sweden; Coll Med, Div Gastroenterol & Hepatol, Dept Med, Mayo Clin, Rochester MN, USA; Coll Med, Div Gastroenterol & Hepatol, Dept Immunol, Mayo Clin, Rochester MN, USA.ORCID iD: 0000-0003-1024-5602
Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Dept Med, Mayo Clin, Rochester MN, USA; Coll Med, Div Gastroenterol & Hepatol, Dept Immunol, Mayo Clin, Rochester MN, USA.ORCID iD: 0000-0003-1941-9090
Div Gastroenterol, Dept Med, London Hlth Sci Ctr, London ON, Canada.
Dept Med, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden.
2013 (English)In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 48, no 2, p. 176-182Article in journal (Refereed) Published
Abstract [en]

Background and aim. Case reports suggest an association between hereditary hemochromatosis (HH) and celiac disease (CD), but estimates of association are lacking. We estimated the association between HH and CD in a population-based study. Material and methods. Case-control study. We identified 29,096 individuals with biopsy-verified CD (equal to villous atrophy, Marsh stage III) through biopsy reports from all 28 pathology departments in Sweden. We then investigated the risk of a clinical diagnosis of HH in CD and in 144,522 controls matched for age, sex, county and calendar year. Conditional logistic regression was used to calculate odds ratios (ORs) for CD in patients with HH. Results. HH was seen in 30 patients with CD and in 60 matched controls. HH was hence associated with an increased risk of CD (OR = 2.30; 95% CI = 1.53-3.45). Restricting HH to individuals with at least two records of HH, the OR for CD was 2.54 (95% CI = 1.57-4.11), with a similar risk estimate when we only looked at HH diagnosed before CD (and matched date in controls) (OR = 2.64; 95% CI = 1.24-5.60). Conclusion. HH seems to be associated with an increased risk of CD.

Place, publisher, year, edition, pages
2013. Vol. 48, no 2, p. 176-182
Keywords [en]
autoimmunity, celiac, hemochromatosis, inflammation
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-56620DOI: 10.3109/00365521.2012.749511ISI: 000313675600006PubMedID: 23256862OAI: oai:DiVA.org:oru-56620DiVA, id: diva2:1083343
Available from: 2017-03-21 Created: 2017-03-21 Last updated: 2018-05-28Bibliographically approved

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Ludvigsson, Jonas F.Murray, Joseph A.
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