oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Influenza H1N1 vaccination and adverse pregnancy outcome
Orebro University Hospital. Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.;Orebro Univ Hosp, Dept Pediat, Orebro, Sweden..ORCID iD: 0000-0003-1024-5602
Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.;Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Turin, Italy.;CPO Piemonte, Turin, Italy..
Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden..
Univ Turin, Dept Med Sci, Canc Epidemiol Unit, Turin, Italy.;CPO Piemonte, Turin, Italy..ORCID iD: 0000-0003-0316-9402
Show others and affiliations
2013 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 28, no 7, 579-588 p.Article in journal (Refereed) Published
Abstract [en]

Although vaccines against influenza can reduce maternal morbidity and mortality, large-scale data on adverse effects in the offspring are scarce. Historical cohort study in Stockholm County, Sweden. We linked H1N1 vaccination data (Pandemrix(A (R)), a mono-valent AS03 adjuvanted H1N1 vaccine) with pregnancy and birth data from 21,087 women with singleton offspring conceived between February 2009 and January 2010 (vaccinated during pregnancy: n = 13,297 vs. unvaccinated: n = 7,790). Data were analysed by conceptualizing the observational cohort as a series of nested cohorts defined at each week of gestation. Logistic regression estimated odds ratios (ORs) for low birth weight (LBW, < 2,500 g), preterm birth (< 37 completed weeks), small-for-gestational age (SGA, < 10th percentile of the gestational age-specific birth weight within the cohort), low 5-min Apgar score (< 7), and caesarean section. Data were adjusted for potential confounders, including maternal age, body mass index, smoking, parity, civil status and comorbidities. Compared with infants of non-vaccinated women, infants of vaccinated women had similar adjusted ORs (95 % CI) for LBW (0.91; 0.79-1.04), preterm birth (0.99; 0.89-1.10), SGA (0.97; 0.90-1.05), low Apgar score (1.05, 0.84-1.31), and a marginal risk reduction for caesarean section (0.94, 0.89-0.99). H1N1 vaccination during pregnancy, using an AS03-adjuvanted vaccine, does not appear to adversely influence offspring risks of LBW, preterm birth, SGA, or low Apgar score. Our results suggest that this vaccine is safe for the offspring when used in different stages of pregnancy.

Place, publisher, year, edition, pages
2013. Vol. 28, no 7, 579-588 p.
Keyword [en]
Child, H1N1, Immunization, Influenza, Small-for-gestational-age, Pregnancy, Preterm birth, Vaccination
National Category
Public Health, Global Health, Social Medicine and Epidemiology Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:oru:diva-56624DOI: 10.1007/s10654-013-9813-zISI: 000323836900006PubMedID: 23715672OAI: oai:DiVA.org:oru-56624DiVA: diva2:1083353
Available from: 2017-03-21 Created: 2017-03-21 Last updated: 2017-03-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ludvigsson, Jonas F.Richiardi, Lorenzo
By organisation
Orebro University Hospital
In the same journal
European Journal of Epidemiology
Public Health, Global Health, Social Medicine and EpidemiologyEnvironmental Health and Occupational Health

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 60 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf