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Epigenetic activation of immune genes in cervical cancer
Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.
Orebro University Hospital. Department of Laboratory Medicine.
Department of Medical Biosciences, Unit of Clinical Chemistry, Umeå University, Umeå, Sweden.
Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia.ORCID iD: 0000-0001-6178-8418
2014 (English)In: Immunology Letters, ISSN 0165-2478, E-ISSN 1879-0542, Vol. 162, no 2, 256-257 p.Article in journal (Refereed) Published
Abstract [en]

Immune system provides us protection from infectious pathogens and tumors formation during lifetime. Cervical cancer (CC), and its cause, human papillomavirus (HPV) are both challenges for the immune system. We present here evidence of epigenetic activation of immune system genes in CC. Illumina Infinium Human Methylation 450 K BeadChip identified genes, which were all significantly hypomethylated in CC tissue versus normal tissue. The GeneMANIA computer program identified a tight network between those genes. The most strongly correlated genes based on their function are immune effectors' process (AIM2, BST2, BTN3A3, and IL12RB1) and response to virus related genes (AIM2, BST2, and IL12RB1). Thus, activation of those genes through demethylation is probably triggered by HPV oncogenes. In conclusion, the immune system of women who do not develop CC is probably activated earlier through DNA demethylation.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 162, no 2, 256-257 p.
National Category
Immunology in the medical area
Research subject
Immunology
Identifiers
URN: urn:nbn:se:oru:diva-56647DOI: 10.1016/j.imlet.2014.09.019ISI: 000347264300023ScopusID: 2-s2.0-84912138354OAI: oai:DiVA.org:oru-56647DiVA: diva2:1083433
Available from: 2017-03-21 Created: 2017-03-21 Last updated: 2017-03-21Bibliographically approved

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CiteExportLink to record
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