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Correlation between rises in Chlamydia pneumoniae-specific antibodies, platelet activation and lipid peroxidation after percutaneous coronary intervention
Cardiovascular Inflammation Research Centre (CIRC), Department of Medicine and Health, Linköping University, Linköping, Sweden.
Cardiovascular Inflammation Research Centre (CIRC), Department of Medicine and Health, Linköping University, Linköping, Sweden.
Department of Health and Society, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Department of Cardiology, Linköping University Hospital, Linköping University, Linköping, Sweden.
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2008 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 27, no 7, 503-511 p.Article in journal (Refereed) Published
Abstract [en]

We recently showed that Chlamydia pneumoniae activates platelets in vitro, with an associated oxidation of low-density lipoproteins. The aim of this study was to investigate whether C. pneumoniae is released during percutaneous coronary intervention (PCI) and, thereby, causes platelet activation and lipid peroxidation. Seventy-three patients undergoing coronary angiography and following PCI or coronary artery bypass graft (CABG) and 57 controls were included in the study. C. pneumoniae antibodies, serotonin and lipid peroxidation were measured before and 24 h, 1 month and 6 months after angiography. The results show that serum C. pneumoniae IgA concentrations were significantly higher in patients than in the controls. Furthermore, in 38% of the C. pneumoniae IgG positive patients, the C. pneumoniae IgG concentration increased 1 month after PCI. The levels of C. pneumoniae IgG antibodies 1 month after PCI correlated with plasma-lipid peroxidation (r = 0.91, P < 0.0001) and platelet-derived serotonin (r = 0.62, P = 0.02). There was no elevation in the total serum IgG 1 month after PCI. In conclusion, the present results suggest that PCI treatment of coronary stenosis releases C. pneumoniae from the atherosclerotic lesions, which leads to platelet activation and lipid peroxidation.

Place, publisher, year, edition, pages
Springer, 2008. Vol. 27, no 7, 503-511 p.
National Category
Infectious Medicine Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-56663DOI: 10.1007/s10096-008-0465-yISI: 000256755000003PubMedID: 18350325ScopusID: 2-s2.0-45449111944OAI: oai:DiVA.org:oru-56663DiVA: diva2:1083516
Available from: 2017-03-21 Created: 2017-03-21 Last updated: 2017-04-13Bibliographically approved

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CiteExportLink to record
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