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Allergy-related diseases and recurrent abdominal pain during childhood - a birth cohort study
Stockholm South Gen Hosp, Sachs Children & Youth Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Med, Clin Epidemiol Unit, SE-17176 Stockholm, Sweden.;Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, SE-17176 Stockholm, Sweden..
Karolinska Inst, Inst Environm Med, SE-17176 Stockholm, Sweden.;Univ Uppsala Hosp, Dept Womens & Childrens Hlth, Uppsala, Sweden..
Karolinska Inst, Dept Med, Clin Epidemiol Unit, SE-17176 Stockholm, Sweden..
Orebro University Hospital. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-1024-5602
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2014 (English)In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 40, no 11-12, 1349-1358 p.Article in journal (Refereed) Published
Abstract [en]

Background: Allergy and immune dysregulation may have a role in the pathophysiology of recurrent abdominal pain of functional origin, but previous studies of allergy-related diseases and abdominal pain have contradictory results.

Aim: To examine the association between allergy-related diseases or sensitisation during childhood and abdominal pain at age 12years.

Methods: In this birth cohort study of 4089 children, parents answered questionnaires regarding asthma, allergic rhinitis, eczema and food hypersensitivity (allergy-related diseases') at ages 0,1,2,4,8 and 12years. Blood for analyses of allergen-specific IgE was sampled at 4 and 8years. At 12years, the children answered questions regarding abdominal pain. Children with coeliac disease or inflammatory bowel disease were excluded. Associations were examined using multivariable logistic regression.

Results: Among 2610 children with complete follow-up, 9% (n=237) reported abdominal pain at 12years. All allergy-related diseases were associated with concurrent abdominal pain at 12years and the risk increased with increasing number of allergy-related diseases (P for trend <0.001). Asthma at 1 and 2years and food hypersensitivity at 8years were significantly associated with abdominal pain at 12years. There was an increased risk of abdominal pain at 12years in children sensitised to food allergens at 4 or 8years, but in stratified analyses, this was confined to children whose parents had not reported food hypersensitivity at time of sensitisation.

Conclusion: Allergy-related diseases as well as sensitisation to food allergens were associated with an elevated risk of abdominal pain, and the risk increased with the number of allergy-related diseases.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2014. Vol. 40, no 11-12, 1349-1358 p.
National Category
Gastroenterology and Hepatology Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:oru:diva-56689DOI: 10.1111/apt.12965ISI: 000345324000011PubMedID: 25270840ScopusID: 2-s2.0-84909584672OAI: oai:DiVA.org:oru-56689DiVA: diva2:1083666
Available from: 2017-03-22 Created: 2017-03-22 Last updated: 2017-03-22Bibliographically approved

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