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EXPRESS study shows significant regional differences in 1-year outcome of extremely preterm infants in Sweden
Dept Womens & Childrens Hlth, Uppsala Univ, Uppsala, Sweden; Inst Clin Sci, Dept Pediat, Umeå Univ, Umeå, Sweden.
Dept Womens & Childrens Hlth, Uppsala Univ, Uppsala, Sweden.
Dept Pediat, Karolinska Univ Hosp, Stockholm, Sweden.ORCID iD: 0000-0001-9517-0261
Dept Pediat, Lund Univ, Lund, Sweden.
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2014 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 103, no 1, p. 27-37Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of this study was to investigate differences in mortality up to 1year of age in extremely preterm infants (before 27weeks) born in seven Swedish healthcare regions.

Methods: National prospective observational study of consecutively born, extremely preterm infants in Sweden 2004-2007. Mortality was compared between regions. Crude and adjusted odds ratios and 95% CI were calculated.

Results: Among 844 foetuses alive at mother's admission for delivery, regional differences were identified in perinatal mortality for the total group (22-26weeks) and in the stillbirth and perinatal and 365-day mortality rates for the subgroup born at 22-24weeks. Among 707 infants born alive, regional differences were found both in mortality before 12h and in the 365-day mortality rate for the subgroup (22-24weeks) and for the total group (22-26weeks). The mortality rates were consistently lower in two healthcare regions. There were no differences in the 365-day mortality rate for infants alive at 12h or for infants born at 25weeks. Neonatal morbidity rates among survivors were not higher in regions with better survival rates. Perinatal practices varied between regions.

Conclusion: Mortality rates in extremely preterm infants varied considerably between Swedish healthcare regions in the first year after birth, particularly between the most immature infants.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2014. Vol. 103, no 1, p. 27-37
Keywords [en]
Cohort study, Extremely preterm infant, Morbidity, Mortality, Outcome
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-56713DOI: 10.1111/apa.12421ISI: 000328736300013PubMedID: 24053771Scopus ID: 2-s2.0-84890957023OAI: oai:DiVA.org:oru-56713DiVA, id: diva2:1083821
Funder
Swedish Research Council, 2006-3858 2009-4250
Note

Funding Agencies:

Swedish Neonatal Society

Evy and Gunnar Sandberg Foundation 

Available from: 2017-03-22 Created: 2017-03-22 Last updated: 2018-06-24Bibliographically approved

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