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Natural history of recurrences in endometrial carcinoma
Örebro University Hospital. Department of Oncology, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-5063-631X
Department of Obstetrics and Gynecology, University Hospital, Örebro, Sweden.
Department of Oncology, University Hospital, Örebro, Sweden.
2014 (English)In: Oncology Letters, ISSN 1792-1074, E-ISSN 1792-1082, Vol. 8, no 4, p. 1800-1806Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to evaluate the natural history of endometrial cancer recurrences with regard to predictive and prognostic factors. Between 1990 and 1999, 100 patients were treated for recurrences of endometrial carcinoma (all FIGO stages). Overall, 90 tumors were of endometrioid type. A total of 82 patients were treated with surgery, 41 patients received adjuvant external irradiation and 91 patients received vaginal brachytherapy. The median time to recurrence (TTR) was 32 months. The recurrences were treated using a combination of high-dose-rate brachytherapy and external pelvic irradiation in 35 cases. In addition, 44 patients were treated with chemotherapy and 21 patients received other types of therapy. The complete remission rate was 29% and the overall response rate was 44%. Among patients treated with radiotherapy, the response rate was 88% and, for those treated with chemotherapy, the rate was 33%. The local control of vaginal recurrences treated with combined radiotherapy was 93%. In 45 patients (45%) a second recurrence was identified and a third recurrence occurred in 12 patients. The overall five-year survival rate was 44%. Age, FIGO grade, nuclear grade, TTR and response to treatment were found to be independent and significant prognostic factors for overall survival rate. Locoregional recurrences were associated with a generalized extra-pelvic disease in 63% of the cases.

Place, publisher, year, edition, pages
Spandidos Publications , 2014. Vol. 8, no 4, p. 1800-1806
Keywords [en]
endometrial carcinoma, recurrences, natural history, radiotherapy, chemotherapy
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-56722DOI: 10.3892/ol.2014.2362ISI: 000342725400074Scopus ID: 2-s2.0-84931956907OAI: oai:DiVA.org:oru-56722DiVA, id: diva2:1083858
Available from: 2017-03-22 Created: 2017-03-22 Last updated: 2018-06-24Bibliographically approved

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