Reversibility of antibiotic resistance
2014 (English)In: Upsala Journal of Medical Sciences, ISSN 0300-9734, E-ISSN 2000-1967, Vol. 119, no 2, 142-148 p.Article, review/survey (Refereed) Published
Although theoretically attractive, the reversibility of resistance has proven difficult in practice, even though antibiotic resistance mechanisms induce a fitness cost to the bacterium. Associated resistance to other antibiotics and compensatory mutations seem to ameliorate the effect of antibiotic interventions in the community. In this paper the current understanding of the concepts of reversibility of antibiotic resistance and the interventions performed in hospitals and in the community are reviewed.
Place, publisher, year, edition, pages
Informa Healthcare, 2014. Vol. 119, no 2, 142-148 p.
Antibiotic resistance, fitness, intervention
IdentifiersURN: urn:nbn:se:oru:diva-56728DOI: 10.3109/03009734.2014.903323ISI: 000336526100012PubMedID: 24836051ScopusID: 2-s2.0-84900861351OAI: oai:DiVA.org:oru-56728DiVA: diva2:1083932