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A study of docetaxel weekly or every three weeks in combination with carboplatin as first line chemotherapy in epithelial ovarian cancer: Hematological and non-hematological toxicity profiles
Orebro University Hospital. Dept Oncol.
Univ Hosp, Dept Oncol, S-70185 Orebro, Sweden..
Univ Hosp, Dept Oncol, S-70185 Orebro, Sweden..
Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden..
2013 (English)In: Oncology Letters, ISSN 1792-1074, E-ISSN 1792-1082, Vol. 5, no 4, 1140-1148 p.Article in journal (Refereed) Published
Abstract [en]

The purpose of this study was to compare the toxicity profiles of docetaxel administered on a weekly schedule and the standard three-week schedule in the treatment of advanced primary ovarian carcinoma. Eligible patients were treated with intravenous docetaxel (30 mg/m(2)) on days 1, 8 and 15, and carboplatin (AUC 5) on day 1 or with docetaxel (75 mg/m(2)) and carboplatin (AUC 5) on day 1; Q21 days for 6 cycles. This study was a pooled study of two primary phase II studies. A total of 108 patients received the weekly schedule and 59 patients received the three-week schedule. All patients were evaluated for toxicity. The overall response rate was 79% and the biochemical response 93% for the weekly schedule. The median overall survival rate was 35.3 months. Neutropenia was significantly more common (ANOVA; p<0.0001) in the three-week group than in the weekly group during all six courses of chemotherapy. Fever and infections were also more common in this group. Thrombocytopenia and anemia were slightly more common in the weekly group. Fatigue, epiphora, nail changes and taste disturbances were specific side-effects following weekly docetaxel. Peripheral sensory neuropathy (grade 1-2) increased with every cycle of treatment, but in a similar manner in the two groups. Grade 3-4 neuropathy was not recorded. Oral mucositis and myalgia were two side-effects associated with the three-week schedule. Nausea and vomiting, diarrhea and dyspnea were a limited problem in both groups. Cardiac toxicity was rare and did not differ between the two docetaxel schedules. The weekly administration was favored due to the lower rates of neutropenia, fever, infections, oral mucositis and myalgia. However, epiphora and nail changes were specific side-effects of the weekly treatment. Both regimens appeared to be rather well tolerated with similar compliance (66 and 70%) with regard to completion of the planned six courses of chemotherapy.

Place, publisher, year, edition, pages
2013. Vol. 5, no 4, 1140-1148 p.
Keyword [en]
ovarian cancer, docetaxel, carboplatin, weekly administration, 3-week administration, hematological toxicity, non-hematological toxicity
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-56748DOI: 10.3892/ol.2013.1146ISI: 000321003100009OAI: oai:DiVA.org:oru-56748DiVA: diva2:1083982
Available from: 2017-03-23 Created: 2017-03-23 Last updated: 2017-03-23Bibliographically approved

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