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Reference Values for Clinical Laboratory Parameters in Young Adults in Maputo, Mozambique
Inst Nacl Sau, Maputo, Mozambique.;Karolinska Inst, Dept Lab Med, Huddinge, Sweden.;Eduardo Mondlane Univ, Fac Med, Maputo, Mozambique..
Inst Nacl Sau, Maputo, Mozambique..
Inst Nacl Sau, Maputo, Mozambique..
Inst Nacl Sau, Maputo, Mozambique..
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2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 5, e97391Article in journal (Refereed) Published
Abstract [en]

Background: Clinical laboratory reference values from North American and European populations are currently used in most Africans countries due to the absence of locally derived reference ranges, despite previous studies reporting significant differences between populations. Our aim was to define reference ranges for both genders in 18 to 24 year-old Mozambicans in preparation for clinical vaccine trials.

Methods: A cross-sectional study including 257 volunteers (102 males and 155 females) between 18 and 24 years was performedat a youth clinic in Maputo, Mozambique. All volunteers were clinically healthy and human immunodeficiency virus, Hepatitis B virus and syphilis negative. Median and 95% reference ranges were calculated for immunological, hematological and chemistry parameters. Ranges were compared with those reported based on populations in other African countries and the US. The impact of applying US NIH Division of AIDS (DAIDS) toxicity tables was assessed.

Results: The immunology ranges were comparable to those reported for the US and western Kenya. There were significant gender differences in CD4(+) T cell values 713 cells/mu L in males versus 824 cells/mu L in females (p < 0.0001). Hematologic values differed from the US values but were similar to reports of populations in western Kenya and Uganda. The lower and upper limits of the ranges for hemoglobin, hematocrit, red blood cells, white blood cells and lymphocytes were somewhat lower than those from these African countries. The chemistry values were comparable to US values, with few exceptions. The upper limits for ALT, AST, bilirubin, cholesterol and triglycerides were higher than those from the US. DAIDStables for adverse events predicted 297 adverse events and 159 (62%) of the volunteers would have been excluded.

Conclusion: This study is the first to determine normal laboratory parameters in Mozambique. Our results underscore the necessity of establishing region-specific clinical reference ranges for proper patient management and safe conduct of clinical trials.

Place, publisher, year, edition, pages
Public Library of Science , 2014. Vol. 9, no 5, e97391
National Category
Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:oru:diva-56752DOI: 10.1371/journal.pone.0097391ISI: 000336857400089PubMedID: 24827458Scopus ID: 2-s2.0-84901370725OAI: oai:DiVA.org:oru-56752DiVA: diva2:1083991
Note

Funding Agencies:

The Regional HIV/AIDS Team for Africa

Embassy of Sweden

Sida  2150012801

Available from: 2017-03-23 Created: 2017-03-23 Last updated: 2017-03-23Bibliographically approved

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