Neisseria gonorrhoeae Strain with High-Level Resistance to Spectinomycin Due to a Novel Resistance Mechanism (Mutated Ribosomal Protein S5) Verified in Norway
2013 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 57, no 2, 1057-1061 p.Article in journal (Refereed) Published
Gonorrhea may become untreatable, and new treatment options are essential. Verified resistance to spectinomycin is exceedingly rare. However, we describe a high-level spectinomycin-resistant (MIC, >1,024 mu g/ml) Neisseria gonorrhoeae strain from Norway with a novel resistance mechanism. The resistance determinant was a deletion of codon 27 (valine) and a K28E alteration in the ribosomal protein 5S. The traditional spectinomycin resistance gene (16S rRNA) was wild type. Despite this exceedingly rare finding, spectinomycin available for treatment of ceftriaxone-resistant urogenital gonorrhea would be very valuable.
Place, publisher, year, edition, pages
2013. Vol. 57, no 2, 1057-1061 p.
Microbiology in the medical area Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:oru:diva-56782DOI: 10.1128/AAC.01775-12ISI: 000313896500051PubMedID: 23183436OAI: oai:DiVA.org:oru-56782DiVA: diva2:1084087