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Verified clinical failure with cefotaxime 1g for treatment of gonorrhoea in the Netherlands: a case report
Public Health Laboratory, Cluster of Infectious Diseases, Amsterdam Health Service, Amsterdam, Netherlands; Department of Microbiology, Onze Lieve Vrouwe Gasthuis General Hospital, Amsterdam, Netherlands.
Department of Microbiology, Onze Lieve Vrouwe Gasthuis General Hospital, Amsterdam, Netherlands.
Department of Laboratory Medicine, WHO Collaborating Centre for Gonorrhoea and Other STIs, Örebro University Hospital, Örebro, Sweden.
Integral Physician Practice West, Amsterdam, Netherlands.
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2014 (English)In: Sexually Transmitted Infections, ISSN 1368-4973, E-ISSN 1472-3263, Vol. 90, no 7, 513-514 p.Article in journal (Refereed) Published
Abstract [en]

We describe the first case of treatment failure of gonorrhoea with a third generation cephalosporin, cefotaxime 1g intramuscularly, in the Netherlands. The case was from a high-frequency transmitting population (men having sex with men) and was caused by the internationally spreading multidrug-resistant gonococcal NG-MAST ST1407 clone. The patient was clinically cured after treatment with ceftriaxone 500 mg intramuscularly and this is the only third generation cephalosporin that should be used for first-line empiric treatment of gonorrhoea. Increased awareness of failures with third generation cephalosporins, enhanced monitoring and appropriate verification of treatment failures including more frequent test-of-cures, and strict adherence to regularly updated treatment guidelines are essential globally.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2014. Vol. 90, no 7, 513-514 p.
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-56786DOI: 10.1136/sextrans-2014-051552ISI: 000344104100003PubMedID: 25114322Scopus ID: 2-s2.0-84910674698OAI: oai:DiVA.org:oru-56786DiVA: diva2:1084106
Available from: 2017-03-23 Created: 2017-03-23 Last updated: 2017-03-23Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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  • de-DE
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