Verified clinical failure with cefotaxime 1g for treatment of gonorrhoea in the Netherlands: a case report
2014 (English)In: Sexually Transmitted Infections, ISSN 1368-4973, E-ISSN 1472-3263, Vol. 90, no 7, 513-514 p.Article in journal (Refereed) Published
We describe the first case of treatment failure of gonorrhoea with a third generation cephalosporin, cefotaxime 1g intramuscularly, in the Netherlands. The case was from a high-frequency transmitting population (men having sex with men) and was caused by the internationally spreading multidrug-resistant gonococcal NG-MAST ST1407 clone. The patient was clinically cured after treatment with ceftriaxone 500 mg intramuscularly and this is the only third generation cephalosporin that should be used for first-line empiric treatment of gonorrhoea. Increased awareness of failures with third generation cephalosporins, enhanced monitoring and appropriate verification of treatment failures including more frequent test-of-cures, and strict adherence to regularly updated treatment guidelines are essential globally.
Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2014. Vol. 90, no 7, 513-514 p.
IdentifiersURN: urn:nbn:se:oru:diva-56786DOI: 10.1136/sextrans-2014-051552ISI: 000344104100003PubMedID: 25114322ScopusID: 2-s2.0-84910674698OAI: oai:DiVA.org:oru-56786DiVA: diva2:1084106