Increased Risk of IgA Nephropathy Among Individuals With Celiac Disease
2013 (English)In: Journal of Clinical Gastroenterology, ISSN 0192-0790, E-ISSN 1539-2031, Vol. 47, no 8, 678-683 p.Article in journal (Refereed) Published
Goal: To determine the risk of future biopsy-verified IgA nephropathy (IgAN) among individuals with biopsy-verified celiac disease (CD). Background: Individuals with CD suffer increased risk of end-stage renal disease. An association between CD and IgAN has been suggested; however, results have been inconclusive and no previous study has considered the risk of IgAN in biopsy-verified CD. Study: We performed a population-based prospective cohort study. We identified 27,160 individuals with CD (Marsh stage III) and no previous renal disease through small-intestinal biopsy reports obtained between July 1969 and February 2008 in all (n=28) Swedish pathology departments. Individuals with IgAN were identified by biopsy reports acquired at the 4 Swedish pathology departments specialized in renal pathology. Cox regression analysis was used to determine the risk of future IgAN among individuals with CD compared with 133,949 age-matched and sex-matched reference individuals. Results: Seven (0.026%) individuals with CD and 11 (0.008%) reference individuals developed IgAN. We found an increased risk of biopsy-verified IgAN among individuals with CD [hazard ratio, 3.03; 95% confidence interval, 1.22-7.56]. The risk increase remained statistically significant after adjustment for prior liver disease and country of birth. Conclusions: Individuals with CD suffer a 3-fold increased risk of future IgAN. Our findings warrant awareness of renal function in individuals with CD.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2013. Vol. 47, no 8, 678-683 p.
celiac disease, IgA nephropathy, renal disease
Gastroenterology and Hepatology
IdentifiersURN: urn:nbn:se:oru:diva-56789DOI: 10.1097/MCG.0b013e318284792eISI: 000325703000005PubMedID: 23442839OAI: oai:DiVA.org:oru-56789DiVA: diva2:1084124