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The risk of renal disease is increased in lambda myeloma with bone marrow amyloid deposits
Örebro University Hospital. Department of Medicine, Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK. (Clinical Epidemiology and Biostatistics)ORCID iD: 0000-0001-6328-5494
Örebro University, School of Medical Sciences. Department of Transfusion Medicine, Faculty of Medical Sciences, Örebro University, Örebro, Sweden. (Clinical Epidemiology and Biostatistics)
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
2017 (English)In: Journal of Blood Medicine, ISSN 1179-2736, Vol. 8, p. 29-34Article in journal (Refereed) Published
Abstract [en]

Background: Light chain amyloidosis (AL) is a rare deposition disease and is present in 10-15% of patients with myeloma (MM). In contrast to symptomatic AL in MM, presence of bone marrow (BM) amyloid deposits (AD) in MM is not connected to kidney damage. Renal AD but not BM-AD occur mostly in MM with lambda paraprotein (lambda MM).

Methods: We investigated amyloid presence in BM clots taken at diagnosis in 84 patients with symptomatic MM and compared disease characteristics in MM with kappa paraprotein (kappa MM)/lambda MM with and without BM-AD.

Results: Lambda MM with BM-AD was compared with kappa MM without BM-AD, kappa MM with BM-AD, and lambda MM without BM-AD: lambda MM with BM-AD patients had a significantly higher mean creatinine level (4.23 mg/dL vs 1.69, 1.14, and 1.28 mg/dL, respectively) and a higher proportion presented with severe kidney failure (6/11 [55%] vs 6/32 [19%], 1/22 [5%], and 3/19 [16%], respectively). Proteinuria was more common in lambda MM with BM-AD patients compared with kappa MM without BM-AD patients (8/11 [73%] vs 5/32 [16%], respectively).

Conclusion: Kidney damage was more common in lambda MM with BM-AD indicating presence of renal AD.

Place, publisher, year, edition, pages
DOVE Medical Press Ltd. , 2017. Vol. 8, p. 29-34
Keywords [en]
plasma cells, neoplasms, amyloidosis, renal insufficiency, proteinuria
National Category
Hematology
Identifiers
URN: urn:nbn:se:oru:diva-56847DOI: 10.2147/JBM.S129516ISI: 000395472700001PubMedID: 28293126Scopus ID: 2-s2.0-85016315664OAI: oai:DiVA.org:oru-56847DiVA, id: diva2:1085116
Available from: 2017-03-28 Created: 2017-03-28 Last updated: 2018-07-30Bibliographically approved

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Montgomery, ScottBefekadu, RahelHahn-Strömberg, Victoria

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