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Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-9635-0341
Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden; Department of Medicine, Avesta Hospital, Avesta, Sweden.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0001-5460-8888
Örebro University, School of Health Sciences. Orebro University Hospital. Division of Gastroenterology.
2017 (English)In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 23, no 7, 1319-1324 p.Article in journal (Refereed) Published
Abstract [en]

One to six percent of patients with microscopic colitis are refractory to medical treatment. The effect of faecal microbiota transplantation (FMT) in active collagenous colitis (CC) has, to the best of our knowledge, never been reported before. Here, we report the effect of repeated FMT in a patient with CC. The patient presented with severe symptoms including profuse diarrhea and profound weight loss. Although she responded to budesonide in the beginning, she became gradually refractory to medical treatment, and was therefore treated with FMT. The patient remained in remission for 11 mo after the third faecal transplantation. The immunomodulatory effect of the therapy was evaluated using flow cytometry, which showed alterations in the profile of intraepithelial and lamina propria lymphocyte subsets after the second transplantation. Our observations indicate that FMT can have an effect in CC, which support the hypothesis that luminal factors, influencing the intestinal microbiota, are involved in the pathogenesis of CC.

Place, publisher, year, edition, pages
Baishideng Publishing Group Co , 2017. Vol. 23, no 7, 1319-1324 p.
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-56987DOI: 10.3748/wjg.v23.i7.1319ISI: 000394459900021PubMedID: 28275312Scopus ID: 2-s2.0-85014906903OAI: oai:DiVA.org:oru-56987DiVA: diva2:1087859
Note

Funding Agency:

Örebro University Hospital Research Foundation (Nyckelfonden)

Available from: 2017-04-10 Created: 2017-04-10 Last updated: 2017-04-10Bibliographically approved

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Gunaltay, SezinHultgren Hörnquist, ElisabethBohr, Johan
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CiteExportLink to record
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Citation style
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