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Coupling Supercritical Fluid Chromatography to Positive Ion Atmospheric Pressure Ionization Mass Spectrometry: Ionization Optimization of Halogenated Environmental Contaminants
Örebro University, School of Science and Technology, Örebro University, Sweden. Wellington Laboratories Inc., Guelph, Ontario, Canada.
Örebro University, School of Science and Technology, Örebro University, Sweden. Norwegian Institute for Water Research, Oslo, Norway.ORCID iD: 0000-0001-6217-8857
Örebro University, School of Science and Technology, Örebro University, Sweden.ORCID iD: 0000-0002-6330-789X
Chemistry Department, University of Guelph, Guelph, ON, Canada.
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(English)Manuscript (preprint) (Other academic)
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Other Chemistry Topics
Identifiers
URN: urn:nbn:se:oru:diva-57150OAI: oai:DiVA.org:oru-57150DiVA: diva2:1089903
Available from: 2017-04-21 Created: 2017-04-21 Last updated: 2017-04-21Bibliographically approved
In thesis
1. Packed Column Supercritical Fluid Chromatography: Applications in Environmental Chemistry
Open this publication in new window or tab >>Packed Column Supercritical Fluid Chromatography: Applications in Environmental Chemistry
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Although gas and liquid chromatography have emerged as dominant separation techniques in environmental analytical chemistry, these methods do not allow for the concurrent analysis of chemically diverse groups of persistent organic pollutants (POPs). There are also a small number of compounds which are not easily amenable to either of these traditional separation techniques. The main objective of this thesis was to address these issues by demonstrating the applicability of packed column supercritical fluid chromatography (pSFC) coupled to mass spectrometry (MS) in various aspects of environmental chemistry.

First, pSFC/MS analytical methods were developed for legacy POPs (PCDDs, PCDFs, and PCBs) as well as the emerging environmental contaminant Dechlorane Plus (DP), and issues relating to the ionization of target analytes when pSFC was coupled to MS were explored. Novel APPI and APCI reagents (fluorobenzene and triethylamine) were optimized and real samples (water and soil) were analyzed to demonstrate environmental applicability.

The possibility of chiral and preparative scale pSFC separations was then demonstrated through the isolation and characterization of thermally labile hexabromocyclododecane (HBCDD) stereoisomers. The analytical pSFC separation of the α-, β-, and γ-HBCDD enantiomers as well as the δ and ε meso forms was shown to be superior to results obtained using a published LC method.

Finally, technical mixtures of phosphorus flame retardants (RBDPP, BPA-BDPP, and DOPO; a group of related compounds which are challenging to analyze concurrently) were examined using multiple analytical techniques and pSFC was found to be the only method which facilitated the accurate determination of the components of all 3 mixtures. This thesis confirms the potential of pSFC/MS as a fast, green, and cost effective means of separating and analyzing environmental contaminants.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2017. 87 p.
Series
Örebro Studies in Chemistry, ISSN 1651-4270 ; 19
Keyword
Supercritical Fluid Chromatography, Mass Spectrometry, Ionization, POPs, APPI, APCI, chiral, achiral, packed column
National Category
Other Chemistry Topics
Identifiers
urn:nbn:se:oru:diva-56826 (URN)978-91-7529-184-0 (ISBN)
Public defence
2017-05-12, Örebro universitet, Billbergska huset, Hörsal B, Fakultetsgatan 1, Örebro, 10:15 (English)
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Available from: 2017-03-27 Created: 2017-03-27 Last updated: 2017-04-25Bibliographically approved

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