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Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study
University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Gothenburg, Sweden.
Örebro University Hospital. Department of Occupational and Environmental Medicine, Örebro University Hospital, Örebro, Sweden .
University of Gothenburg, Gothenburg, Sweden; Sahlgrenska University Hospital, Gothenburg, Sweden.
2017 (English)In: Pituitary, ISSN 1386-341X, E-ISSN 1573-7403, Vol. 20, no 2, 218-224 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Patients with non-functioning pituitary adenomas (NFPA), especially women, have increased mortality. The aim of this study was to investigate whether mortality in NFPA patients has changed during the last two decades.

METHODS: This was a nationwide population-based study including 2795 patients (1502 men, 1293 women) diagnosed with NFPA between 1997 and 2011. Patients were identified and followed in Swedish National Health Registries. Standardized mortality ratios (SMRs) with 95 % confidence intervals were calculated for three time periods at first NFPA diagnosis using the general population as reference.

RESULTS: Mean (±SD) age at NFPA diagnosis was 58.9 ± 16.8 years. Mean (range) follow-up time was 8.3 (0-18) years, resulting in 20,517 patient-years at risk. Surgical treatment and radiotherapy were used in 53 and 5 %, respectively. The prevalence of hypopituitarism was 64 % during the first time period of diagnosis and then declined gradually during the study period (P value for trend <0.0001). The use of pituitary surgery and radiotherapy remained stable. In women, mortality was increased for patients diagnosed between 1997 and 2006 but not for those diagnosed between 2007 and 2011. The SMR in men remained stable throughout the study and did not differ from the general population. During the last time period, 2007-2011, the SMR between men and women did not differ.

CONCLUSIONS: While mortality in men with NFPA remains normal and stable during the last two decades, mortality in women has declined. Decreasing prevalence of pituitary insufficiency may be a plausible explanation for this positive development.

Place, publisher, year, edition, pages
Springer-Verlag New York , 2017. Vol. 20, no 2, 218-224 p.
Keyword [en]
Mortality; Non-functioning pituitary adenoma; Women; Time trends; Hypopituitarism; Surgery
National Category
Cancer and Oncology Endocrinology and Diabetes
Research subject
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-57426DOI: 10.1007/s11102-016-0764-8ISI: 000398474800006PubMedID: 27743172Scopus ID: 2-s2.0-84991093559OAI: oai:DiVA.org:oru-57426DiVA: diva2:1090871
Note

Funding Agency:

Swedish federal government under the ALF agreement on medical training and research

Available from: 2017-04-25 Created: 2017-04-25 Last updated: 2017-10-18Bibliographically approved

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