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Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry
Skåne University Hospital, Lund, Sweden; Stem Cell Center, Lund University, Lund, Sweden.
Skåne University Hospital, Lund, Sweden; Lund University, Lund, Sweden.
Skåne University Hospital, Lund, Sweden; Stem Cell Center, Lund University, Lund, Sweden.
Linköping University Hospital, Linköping, Sweden.
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2017 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 98, no 5, 493-500 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES AND METHODS: To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry.

RESULTS: Of the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60 years vs. 23% at >60 years; P<.0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6 years) and IR groups (1.7 years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5 years for +4, 1.9 years for +21, 1.5 years for +8, 1.1 years for +11, and 0.8 years for +13 (P=.013).

CONCLUSION: AML with single trisomies, with the exception of +13, should be grouped as IR.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017. Vol. 98, no 5, 493-500 p.
Keyword [en]
acute myeloid leukemia, autosomal trisomy, clinical characteristics, survival
National Category
Cancer and Oncology Hematology
Research subject
Oncology; Cancer Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-57401DOI: 10.1111/ejh.12861ISI: 000399882100009PubMedID: 28152233ScopusID: 2-s2.0-85014778341OAI: oai:DiVA.org:oru-57401DiVA: diva2:1092373
Funder
Swedish Research CouncilSwedish Cancer Society
Note

Funding Agencies:

Regional Cancer Centers 

Swedish Association of Local Authorities and Regions (SKL)  

Governmental Funding of Clinical Research within the National Health Service 

Available from: 2017-05-02 Created: 2017-05-02 Last updated: 2017-05-24Bibliographically approved

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