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Helicobacter pylori adapts to chronic infection and gastric disease via ph-responsive baba-mediated adherence
Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.
Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden; Swedish Defence Research Agency, Umeå, Sweden.
Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.
Department of Medical Biochemistry and Biophysics, Umeå University, Umeå, Sweden.
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2017 (English)In: Cell Host and Microbe, ISSN 1931-3128, E-ISSN 1934-6069, Vol. 21, no 3, 376-389 p., S1931-3128(17)30075-6Article in journal (Refereed) Published
Abstract [en]

The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen and that bio-selection and changes in BabA binding properties through mutation and recombination with babA-related genes are selected by differences among individuals and by changes in gastric acidity over time. These processes generate diverse H. pylori subpopulations, in which BabA's adaptive evolution contributes to H. pylori persistence and overt gastric disease.

Place, publisher, year, edition, pages
2017. Vol. 21, no 3, 376-389 p., S1931-3128(17)30075-6
Keyword [en]
Helicobacter pylori, acid responsiveness, adaptation, blood group antigen-binding adhesion, diversity, gastric acidity, gastric cancer, multimerization, polymorphism, subpopulations
National Category
Infectious Medicine Cancer and Oncology Cell and Molecular Biology
Research subject
Cancer Epidemiology; Infectious Diseases; Molecular Cellbiology
Identifiers
URN: urn:nbn:se:oru:diva-57378DOI: 10.1016/j.chom.2017.02.013ISI: 000396375600023PubMedID: 28279347ScopusID: 2-s2.0-85014795847OAI: oai:DiVA.org:oru-57378DiVA: diva2:1093837
Note

Funding agencies:

Vetenskapsradet   

Cancerfonden   

Formas   

J.C. Kempe and Seth M. Kempe Memorial Foundation   

Knut and Alice Wallenberg Foundation  2012.0090 

European Union Seventh Framework Program GastricGlycoExplorer ITN  316929 

Magn. Bergvall's Foundation   

DFG  SFB 900/A1 HA2697/16-1 

ERA-NET and Actions Concertees Inter-Pasteuriennes (ACIP)  FP6 ANR-06-PATHO-00701 

NIH  R01DK063041 CA082312 AI070803 AI081037 

CSIR project, India  37(1640)/14/EMR-II G033717N 12H8416N 

Available from: 2017-05-08 Created: 2017-05-08 Last updated: 2017-05-08Bibliographically approved

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