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Celiac disease is associated with childhood psychiatric disorders: A Population-Based Study.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden;.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden .
Child and Adolescent Psychiatry Research Center, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden; Child and Adolescent Psychiatry Research Center, Stockholm, Sweden.
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2017 (English)In: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 184, 87-93.e1 p., S0022-3476(17)30153-1Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVES: To determine the risk of future childhood psychiatric disorders in celiac disease, assess the association between previous psychiatric disorders and celiac disease in children, and investigate the risk of childhood psychiatric disorders in siblings of celiac disease probands.

STUDY DESIGN: This was a nationwide registry-based matched cohort study in Sweden with 10 903 children (aged <18 years) with celiac disease and 12 710 of their siblings. We assessed the risk of childhood psychiatric disorders (any psychiatric disorder, psychotic disorder, mood disorder, anxiety disorder, eating disorder, psychoactive substance misuse, behavioral disorder, attention-deficit hyperactivity disorder [ADHD], autism spectrum disorder [ASD], and intellectual disability). HRs of future psychiatric disorders in children with celiac disease and their siblings was estimated by Cox regression. The association between previous diagnosis of a psychiatric disorder and current celiac disease was assessed using logistic regression.

RESULTS: Compared with the general population, children with celiac disease had a 1.4-fold greater risk of future psychiatric disorders. Childhood celiac disease was identified as a risk factor for mood disorders, anxiety disorders, eating disorders, behavioral disorders, ADHD, ASD, and intellectual disability. In addition, a previous diagnosis of a mood, eating, or behavioral disorder was more common before the diagnosis of celiac disease. In contrast, siblings of celiac disease probands were at no increased risk of any of the investigated psychiatric disorders.

CONCLUSIONS: Children with celiac disease are at increased risk for most psychiatric disorders, apparently owing to the biological and/or psychological effects of celiac disease.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 184, 87-93.e1 p., S0022-3476(17)30153-1
Keyword [en]
attention-deficit hyperactivity disorder, autism, celiac disease, psychiatric disorder
National Category
Immunology in the medical area
Research subject
Immunology
Identifiers
URN: urn:nbn:se:oru:diva-57377DOI: 10.1016/j.jpeds.2017.01.043PubMedID: 28283256OAI: oai:DiVA.org:oru-57377DiVA: diva2:1093950
Note

Funding agencies:

Swedish Research Council 340-2013-5867, 523-2011-3807, 522-2009-1951

Polish Ministry of Science and Higher Education 903/MOB/2012/0 and IP2012 006972

Karolinska Institute Foundation

Magnus Bergvall Foundation

Swedish Society of Medicine

Swedish Celiac Society

Eli-Lilly and Shire

Available from: 2017-05-08 Created: 2017-05-08 Last updated: 2017-05-14Bibliographically approved

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