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Progestin, estrogen and androgen G-protein coupled receptors in fish gonads
University of Texas at Austin, Marine Science Institute, Port Aransas TX, United States.
University of Texas at Austin, Marine Science Institute, Port Aransas TX, United States.
University of Texas at Austin, Marine Science Institute, Port Aransas TX, United States.
University of Texas at Austin, Marine Science Institute, Port Aransas TX, United States. (Life Science)ORCID iD: 0000-0002-4954-926X
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2006 (English)In: Steroids, ISSN 0039-128X, E-ISSN 1878-5867, Vol. 71, no 4, 310-316 p.Article in journal (Refereed) Published
Abstract [en]

The identities of the membrane receptors mediating the majority of rapid, cell surface-initiated, nongenomic (i.e. nonclassical) steroid actions described to date are unclear. Two novel 7-transmembrane spanning proteins, representing two distinct classes of steroid membrane receptors, membrane progestin receptor alpha (mPRalpha) and a membrane estrogen receptor (mER), GPR30, have recently been identified in several vertebrate species. Evidence that both receptors activate G-proteins and function as G-protein coupled receptors (GPCRs) is briefly reviewed. New data on progestin actions on fish gametes suggest a widespread involvement of mPRalpha in oocyte maturation and sperm hyperactivity in this vertebrate group. Information on the second messenger pathways activated upon estrogen binding to a membrane estrogen receptor in croaker gonads and preliminary evidence for the presence of a GPR30-like protein in fish gonads are discussed. Finally, initial characterization of the ligand binding, G-protein activation and molecular size of a membrane androgen receptor (mAR) in croaker ovaries suggests the presence of a third unique steroid receptor in fish gonads that also may function as a GPCR.

Place, publisher, year, edition, pages
Elsevier, 2006. Vol. 71, no 4, 310-316 p.
Keyword [en]
progestin membrane receptors; estrogen membrane receptors; androgen membrane receptors; GPCRs; sperm motility; fish gonads; nongenomic steroid actions
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-57736DOI: 10.1016/j.steroids.2005.09.015ISI: 000236834700007PubMedID: 16289637ScopusID: 2-s2.0-33645389472OAI: oai:DiVA.org:oru-57736DiVA: diva2:1096570
Available from: 2017-05-18 Created: 2017-05-18 Last updated: 2017-05-18Bibliographically approved

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