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Reading problems and major mental disorders: co-occurrences and familial overlaps in a Swedish nationwide cohort
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, United Kingdom.
Medical Research Council Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, United Kingdom.
Örebro University, School of Medical Sciences. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
Department of Psychological and Brain Sciences, Indiana University, Bloomington IN, United States of America.
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2017 (English)In: Journal of Psychiatric Research, ISSN 0022-3956, E-ISSN 1879-1379, Vol. 91, 124-129 p.Article in journal (Refereed) Published
Abstract [en]

Reading problems often co-occur with ADHD and conduct disorder. However, the patterns of co-occurrence and familial overlap between reading problems and other psychiatric disorders have not been systematically explored. We conducted a register-based cohort study including 8719 individuals with reading problems and their siblings, along with matched comparison individuals. Conditional logistic regressions estimated risks for ADHD, autism, obsessive-compulsive disorder, anorexia nervosa, schizophrenia, bipolar disorder, depression, substance use disorder, and violent/non-violent criminality in individuals with reading problems and their siblings. Diagnoses of psychiatric disorders were physician-assigned and ascertained from the Swedish National Patient Register, and crime convictions from the Swedish National Crime Register. We found that individuals with reading problems had excess risks for all psychiatric disorders (except anorexia nervosa) and criminality, with risk ratios between 1.34 and 4.91. Siblings of individuals with reading problems showed excess risks for ADHD, autism, schizophrenia, bipolar disorder, depression, substance use disorder, and non-violent criminality, with risk ratios between 1.14 and 1.70. In summary, individuals with reading problems had increased risks of virtually all psychiatric disorders, and criminality. The origin of most of these overlaps was familial, in that siblings of individuals with reading problems also had elevated risks of ADHD, autism, schizophrenia, bipolar disorder, depression, substance use disorder, and non-violent criminality. These findings have implications for gene-searching efforts, and suggest that health care practitioners should be alert for signs of psychiatric disorders in families where reading problems exist.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 91, 124-129 p.
Keyword [en]
Reading problems; Psychiatric disorders; Epidemiology
National Category
Psychiatry
Research subject
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-57360DOI: 10.1016/j.jpsychires.2017.03.014ISI: 000404803500016PubMedID: 28343067Scopus ID: 2-s2.0-85016156728OAI: oai:DiVA.org:oru-57360DiVA: diva2:1097052
Note

Funding Agency:

Swedish Foundation for International Cooperation in Research and Higher Education (STINT)

Available from: 2017-05-22 Created: 2017-05-22 Last updated: 2017-10-18Bibliographically approved

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Citation style
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