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Neurovascular Bundle Infiltration Can Explain Local Relapses Using Conformal Radiotherapy of Prostate Cancer
Section of Medical Physics, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Oncology.
Section of Medical Physics, Department of Immunology, Genetics and Pathology, Uppsala University, Rudbecklaboratoriet, Uppsala, Sweden.
2017 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 37, no 4, 1825-1830 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To quantify the impact of decreased margins for two treatment techniques, three-dimensional conformal radiotherapy (3D-CRT) and volumetric-modulated arc therapy (VMAT), on local control in curative treatment of prostate cancer.

MATERIALS AND METHODS: The planning target volume (PTV) margins were decreased in steps of 1 mm from 10 to 1 mm. Treatment plans using 3D-CRT and VMAT technique were produced for all margin sizes and the dose to the neuro vascular bundles (NVB), that was not included in the PTV, was investigated.

RESULTS: Due to the more conformal dose delivery using VMAT, the dose to the NVB decreased more rapidly by VMAT compared to the 3D-CRT plans. The dose difference was significant for margins from 1-7 mm.

CONCLUSION: One should be very cautious before clinical routines are changed, bearing in mind whether the change means more conformal treatment technique, smaller margins or target segmentation in different imaging modalities.

Place, publisher, year, edition, pages
International Institute of Anticancer Research, 2017. Vol. 37, no 4, 1825-1830 p.
Keyword [en]
Prostate cancer; local relapse; radiotherapy; 3D-CRT; VMAT
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-57342DOI: 10.21873/anticanres.11517ISI: 000402167700035PubMedID: 28373447Scopus ID: 2-s2.0-85017442306OAI: oai:DiVA.org:oru-57342DiVA: diva2:1098828
Note

Funding Agency:

"Stiftelsen Onkologiska klinikens i Uppsala forskningsfond" (local foundation)

Available from: 2017-05-26 Created: 2017-05-26 Last updated: 2017-09-25Bibliographically approved

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