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Parkinson's disease and occupational exposures: a systematic literature review and meta-analyses
Örebro University, School of Medical Sciences. Department of Occupational and Environmental Medicine, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-4192-8273
Örebro University, Orebro University School of Business, Örebro University, Sweden. Department of Statistics, Örebro University, Örebro, Sweden; Unit of Intervention and Implementation Research for Worker Health, Institute of Environmental Medicine, Karolinska Institute, Solna, Sweden.
2017 (English)In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 43, no 3, 197-209 p., 3641Article in journal (Refereed) Published
Abstract [en]

Objectives: We conducted a systematic literature review to identify studies fulfilling good scientific epidemiological standards for use in meta-analyses of relevant risk factors for Parkinson's disease.

Methods: Our search identified 103 original publications on associations between work and Parkinson's disease. GRADE guidelines were used to ensure high scientific quality, and reliable guidelines were applied to classify the papers. Of the 103 articles, 47 fulfilled good scientific standards while 56 were methodologically deficient and thus excluded from our meta-analyses.

Results: A total of 23 publications concerned work exposure to pesticides. The weighted relative risk estimate was 1.67 (95% confidence interval 1.42-1.97). A funnel plot and bias test indicated that some publication bias concerning smaller studies might have been present. The risk estimate was not influenced by study design (case-control, cohort, or cross-sectional study) or gender. Higher estimates were found when there was a hereditary taint or onset below age 60. Studies on exposure to metals or electromagnetic fields did not show increased risk.

Conclusions: Using an elaborated quality protocol, there is now strong evidence that exposure to any pesticide involves a ≥50% increased risk for developing Parkinson's disease.

Place, publisher, year, edition, pages
Nordic Association of Occupational Safety and Health , 2017. Vol. 43, no 3, 197-209 p., 3641
Keyword [en]
chemical; electromagnetic field; epidemiology; metal; pesticide; systematic review; welding
National Category
Environmental Health and Occupational Health
Research subject
Occupational and Environmental Medicine
Identifiers
URN: urn:nbn:se:oru:diva-57338DOI: 10.5271/sjweh.3641ISI: 000400705700002PubMedID: 28379585ScopusID: 2-s2.0-85018371645OAI: oai:DiVA.org:oru-57338DiVA: diva2:1102673
Note

Funding Agencies:

AFA Insurance  

Department of Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg 

Available from: 2017-05-30 Created: 2017-05-30 Last updated: 2017-05-31Bibliographically approved

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