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Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies
Department of Health Statistics, Second Military Medical University, Shanghai, China.
Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Mount Sinai St. Luke's and West Medical Center, New York NY, United States.
Mount Sinai St. Luke's and West Medical Center, New York NY, United States.
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2017 (English)In: Nutrition Journal, ISSN 1475-2891, E-ISSN 1475-2891, Vol. 16, 26Article, review/survey (Refereed) Published
Abstract [en]

Background: The findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum magnesium concentration and the risk of hypertension. We aimed to review the evidence from prospective cohort studies and perform a dose-response meta-analysis to investigate the relationship between dietary magnesium intake and serum magnesium concentrations and the risk of hypertension.

Methods: We searched systematically PubMed, EMBASE and the Cochrane Library databases from October 1951 through June 2016. Prospective cohort studies reporting effect estimates with 95% confidence intervals (CIs) for hypertension in more than two categories of dietary magnesium intake and/or serum magnesium concentrations were included. Random-effects models were used to combine the estimated effects.

Results: Nine articles (six on dietary magnesium intake, two on serum magnesium concentration and one on both) of ten cohort studies, including 20,119 cases of hypertension and 180,566 participates, were eligible for inclusion in the meta-analysis. We found an inverse association between dietary magnesium intake and the risk of hypertension [relative risk (RR) = 0.92; 95% CI: 0.86, 0.98] comparing the highest intake group with the lowest. A 100 mg/day increment in magnesium intake was associated with a 5% reduction in the risk of hypertension (RR = 0.95; 95% CI: 0.90, 1.00). The association of serum magnesium concentration with the risk of hypertension was marginally significant (RR = 0.91; 95% CI: 0.80, 1.02).

Conclusions: Current evidence supports the inverse dose-response relationship between dietary magnesium intake and the risk of hypertension. However, the evidence about the relationship between serum magnesium concentration and hypertension is limited.

Place, publisher, year, edition, pages
BioMed Central, 2017. Vol. 16, 26
Keyword [en]
Magnesium, Dietary intake, Serum concentration, Hypertension, Prospective cohort study, Doseresponse relationship
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-57861DOI: 10.1186/s12937-017-0247-4ISI: 000400706200001PubMedID: 28476161Scopus ID: 2-s2.0-85019029338OAI: oai:DiVA.org:oru-57861DiVA: diva2:1104066
Note

Funding Agencies:

Chinese Fourth Round of the Three-year Action Plan on Public Health Discipline and Talent Program: Evidence-based Public Health and Health Economics  15GWZK0901 

Karolinska Institutet doctoral research grant (KID-funds)  

Institute of Environmental Medicine, Karolinska Institutet, Sweden  C62412022 

Available from: 2017-05-31 Created: 2017-05-31 Last updated: 2017-09-19Bibliographically approved

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Hiyoshi, AyakoCao, Yang

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