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Brown Bears (Ursus arctos) Seem Resistant to Atherosclerosis -Despite Highly Elevated Plasma Lipids during Hibernation and Active State
Orebro Univ Hosp, Dept Cardiol, Orebro, Sweden..
Univ Orebro, Dept Clin Med, Orebro, Sweden..
Hedmark Univ Coll, Fac Forestry & Wildlife Management, Campus Evenstad, Norway.;Norwegian Sch Vet Sci, Sect Arctic Vet Med, Tromso, Norway..
Hedmark Univ Coll, Fac Forestry & Wildlife Management, Campus Evenstad, Norway.;Swedish Univ Agr Sci, Fac Forest Sci, Dept Wildlife Fish & Environm Studies, S-90183 Umea, Sweden..
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2012 (English)In: Clinical and Translational Science, ISSN 1752-8054, E-ISSN 1752-8062, Vol. 5, no 3, 269-272 p.Article in journal (Refereed) Published
Abstract [en]

Hibernation is an extreme physiological challenge for the brown bear (Ursus arctos) in which metabolism is based mainly on lipids. The study objective was to compare plasma lipids in hibernating and active free-ranging brown bears and relate them to arterial histopathology. Blood was drawn from seven immobilized free-ranging brown bears (three females, 23 years old) during hibernation in February and from the same bears while active in June and analyzed by enzymatic and automated hematology methods within 48 hours of sampling. Left anterior descending coronary arteries and aortic arches from 12 bears (six females, 1.512 years old) killed in hunting were examined by histopathology. Total plasma cholesterol decreased from hibernation to the active period (11.08 +/- 1.04 mmol/L vs. 7.89 +/- 1.96 mmol/L, P= 0.0028) as did triglyceride (3.16 +/- 0.62 mmol/L vs. 1.44 +/- 0.27 mmol/L, P= 0.00012) and LDL cholesterol (4.30 +/- 0.71 mmol/L vs. 2.02 +/- 1.03 mmol/L, P= 0.0075), whereas HDL cholesterol was unchanged. No atherosclerosis, fatty streaks, foam cell infiltration, or inflammation were seen in any arterial samples. Brown bears tolerate elevated cholesterol levels, obesity, physical inactivity, and circulatory slow flow during hibernation without signs of -atherosclerosis. This species might serve as a reverse translational model for atherosclerosis resistance. Clin Trans Sci 2012; Volume 5: 269272

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2012. Vol. 5, no 3, 269-272 p.
Keyword [en]
apolipoproteins, cholesterol, hibernation physiology, triglycerides
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URN: urn:nbn:se:oru:diva-58327DOI: 10.1111/j.1752-8062.2011.00370.xISI: 000305077100014PubMedID: 22686205OAI: oai:DiVA.org:oru-58327DiVA: diva2:1116038
Available from: 2017-06-27 Created: 2017-06-27 Last updated: 2017-06-27

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