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Pesticide exposure in farming and forestry and the risk of uveal melanoma
Bremen Inst Prevent Res & Social Med, D-28359 Bremen, Germany.;Ruhr Univ Bochum, Inst Prevent & Occupat Med German Social Accid In, Bochum, Germany..
Univ Copenhagen, Inst Publ Hlth, Copenhagen, Denmark..ORCID iD: 0000-0003-4785-5236
UCL, Inst Ophthalmol, London, England..
Univ Zurich, NICER, Zurich, Switzerland..
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2012 (English)In: Cancer Causes and Control, ISSN 0957-5243, E-ISSN 1573-7225, Vol. 23, no 1, 141-151 p.Article in journal (Refereed) Published
Abstract [en]

Since pesticides are disputed risk factors for uveal melanoma, we studied the association between occupational pesticide exposure and uveal melanoma risk in a case-control study from nine European countries.

Incident cases of uveal melanoma and population as well as hospital controls were included and frequency-matched by country, 5-year age groups and sex. Self-reported exposure was quantified with respect to duration of exposure and pesticide application method. We calculated the exposure intensity level based on application method and use of personal protective equipment. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by unconditional logistic regression analyses and adjusted for several potential confounders.

293 case and 3,198 control subjects were interviewed. We did not identify positive associations with activities in farming or forestry, pesticide application or pesticide mixing. No consistent positive associations were seen with exposure intensity level scores either. The only statistically significantly raised association in this study was for exposure to chemical fertilizers in forestry (OR = 8.93; 95% CI 1.73-42.13), but this observation was based on only six exposed subjects. Results did not change when we restricted analyses to morphologically verified cases and excluded proxy interviews as well as cancer controls. We did not observe effect modification by sex or eye color.

Risk estimates for pesticide exposures and occupational activities in agriculture and forestry were not increased and did not indicate a hormonal mechanism due to these exposures.

Place, publisher, year, edition, pages
Springer, 2012. Vol. 23, no 1, 141-151 p.
Keyword [en]
Agriculture, Animal husbandry, Chemical fertilizers, Multicenter study, Ocular melanoma
National Category
Agricultural Occupational Health and Safety Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-58344DOI: 10.1007/s10552-011-9863-zISI: 000297757400014PubMedID: 22052342Scopus ID: 2-s2.0-82955195606OAI: oai:DiVA.org:oru-58344DiVA: diva2:1116909
Funder
Swedish Society of Medicine
Note

Funding Agencies:

European Commission  

DGXII  

Program BIOMED  BMH1 CT 93-1630  ERB CIPD CT 940285 

The strategic Environment Program  92.01.015.7-06 

Danish Epidemiology Science Center  

Danish National Research Foundation  

Ligue Nationale contre le cancer  

Institut National de la Sante et de la Recherche Medicale (INSERM)  4R006A 

French Ministry of Environment  237.01. 94.40182 

Federal Ministry for Education, Science, Research and Technology (BMBF)  01-HP-684/8 

The Italian Association for Cancer Research (AIRC)  

Special Project Oncology  

Compagnia di San Paolo/FIRMS  

MURST, Region Piedmont  

Fondo de Investigacion de la Sanitarie  

Ministerio de Sanidad y Consumo  

Unidad de Investigacion Clinico-Epidemiologica  

Hospital Dr. Peset. Generalitat Valenciana  FISS. 95/0044-01, 96/0043-01 

Departmento de Sanidad y Consumo, Gobierno Vasco  

Fondo de Investigacion de la Sanitaria  

Ayuda a la Investigacion del Departamento de Salud del Gobierno de Navarra  

Swedish Council for Work Life Research  

Research Foundation of the Department of Oncology in Umea  

Lund University Hospital Research Foundation, Gunnar, Arvid  

Elisabeth Nilsson Cancer Foundation  

Örebro County Council Research Committee  

Örebro Medical Center Research Foundation  

John and Augusta Persson Foundation for Scientific Medical Research  

Berta Kamprad Foundation for Cancer Research  

Federation Nationale des Centres de Lutte contre le Cancer  

Fondation de France  955368 

Available from: 2017-06-28 Created: 2017-06-28 Last updated: 2017-10-18Bibliographically approved

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Hardell, Lennart

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