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Validation of the Lund-Malmo, Chronic Kidney Disease Epidemiology (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations to estimate glomerular filtration rate in a large Swedish clinical population
Skane Univ Hosp, Competence Ctr Clin Res, Lund, Sweden..
Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden..
Lund Univ, Dept Radiol, Lasarettet Trelleborg, SE-23185 Trelleborg, Sweden..
Orebro Univ Hosp, Nephrol Sect, Dept Internal Med, Orebro, Sweden..
2012 (English)In: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 46, no 3, 212-222 p.Article in journal (Refereed) Published
Abstract [en]

Objective. The aim of this study was to validate externally the Swedish Lund-Malmo revised creatinine-based glomerular filtration rate (GFR) equations (LM Revised) in a Swedish cohort in comparison with the North American Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology (CKD-EPI) equations. Material and methods. The study included 1397 examinations [median age 61 years, median body mass index (BMI) 26 kg/m(2)] in 996 patients referred for iohexol clearance (median 44 ml/min/1.73 m(2)). Bias, precision [interquartile range (IQR)], accuracy expressed as percentage of estimates +/- 10% (P-10) and +/- 30% (P-30) of measured GFR, and classification ability for five GFR stages (<15, 15-29, 30-59, 60-89 and 90 ml/min/1.73 m(2)) were compared. Results. Overall, all three equations performed satisfactorily: LM Revised, MDRD, CKD-EPI showed, respectively, a median bias of -5.8%, -2.2% and 1.7%, IQR 11.9, 12.3 and 11.7 ml/min/1.73 m(2), P-10 35%, 34% and 38%, P-30 84%, 79% and 79% and correctly classified GFR stages 68%, 65% and 69%. LM Revised was at least as accurate in terms of P-30 as the other equations at GFR intervals <90, while CKD-EPI was the only unbiased and the most accurate equation at 90 ml/min/1.73 m(2). LM Revised was more stable in terms of bias and accuracy across age and BMI groups than MDRD and CKD-EPI. Both MDRD and CKD-EPI overestimated measured GFR among elderly patients and in the small group of underweight men. Conclusion. The ideal all-purpose GFR prediction equation does not exist. LM Revised should be preferred in patients with suspected or known renal insufficiency, while CKD-EPI is most useful in settings where patients with no a priori suspicion of renal impairment are evaluated. Differences in creatinine measurements between laboratories may limit the generalizability of the present validation.

Place, publisher, year, edition, pages
INFORMA HEALTHCARE , 2012. Vol. 46, no 3, 212-222 p.
Keyword [en]
glomerular filtration rate, kidney disease, kidney function tests, renal insufficiency
National Category
Public Health, Global Health, Social Medicine and Epidemiology Urology and Nephrology
Identifiers
URN: urn:nbn:se:oru:diva-58358DOI: 10.3109/00365599.2011.644859ISI: 000304102900008PubMedID: 22250974OAI: oai:DiVA.org:oru-58358DiVA: diva2:1116993
Available from: 2017-06-28 Created: 2017-06-28 Last updated: 2017-06-28

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