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In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea?
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2012 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 56, no 5, 2739-42 p.Article in journal (Refereed) Published
Abstract [en]

Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the first fluoroketolide, solithromycin. Clinical Neisseria gonorrhoeae isolates and reference strains (n = 246), including the two extensively drug-resistant strains H041 and F89 and additional isolates with clinical cephalosporin resistance and multidrug resistance, were examined. The activity of solithromycin was mainly superior to that of other antimicrobials (n = 10) currently or previously recommended for gonorrhea treatment. Solithromycin might be an effective treatment option for gonorrhea.

Place, publisher, year, edition, pages
2012. Vol. 56, no 5, 2739-42 p.
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Infectious Medicine Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:oru:diva-58670DOI: 10.1128/AAC.00036-12PubMedID: 22354296OAI: oai:DiVA.org:oru-58670DiVA: diva2:1121610
Available from: 2017-07-12 Created: 2017-07-12 Last updated: 2017-07-12

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Unemo, Magnus
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Örebro University Hospital
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