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Appropriate Time for Test-of-Cure when Diagnosing Gonorrhoea with a Nucleic Acid Amplification Test
Univ Hosp N Norway, Dept Microbiol & Infect Control, NO-9038 Tromso, Norway..
Univ Hosp N Norway, Dept Microbiol & Infect Control, NO-9038 Tromso, Norway..
Univ Tromso, Dept Microbiol & Virol, Inst Med Biol, Tromso, Norway..
Univ Hosp N Norway, Dept Microbiol & Infect Control, NO-9038 Tromso, Norway..
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2012 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 92, no 3, 316-319 p.Article in journal (Refereed) Published
Abstract [en]

Culture is commonly regarded as the gold standard for diagnosis of Neisseria gonorrhoeae. However, nucleic acid amplification tests (NAATs) have rapidly replaced culture for diagnostics in many settings. The aim of the present study was to investigate the appropriate time for test-of-cure (TOC) when NAATs are used for diagnosis of gonorrhoea. In total, 30 patients (28 men and 2 women) provided urethral, cervical, rectal or pharyngeal specimens for TOC. All included patients, except one who did not return for second TOC before day 19, tested negative within 2 weeks after treatment with cefixime 400 mg x 1. Antimicrobial susceptibility testing showed that 68% of the culture-positive strains were resistant to ciprofloxacin. Thus, the recommended empirical treatment with ciprofloxacin in Norway should be changed immediately. TOC can be performed 2 weeks after treatment when NAATs are used for diagnosis of gonorrhoea.

Place, publisher, year, edition, pages
ACTA DERMATO-VENEREOLOGICA , 2012. Vol. 92, no 3, 316-319 p.
Keyword [en]
TOC, test-of-cure, N. gonorrhoeae, PCR, NAAT
National Category
Infectious Medicine Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:oru:diva-58680DOI: 10.2340/00015555-1275ISI: 000305814300024PubMedID: 22286973OAI: oai:DiVA.org:oru-58680DiVA: diva2:1122201
Available from: 2017-07-12 Created: 2017-07-12 Last updated: 2017-07-12

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CiteExportLink to record
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