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Appropriate Time for Test-of-Cure when Diagnosing Gonorrhoea with a Nucleic Acid Amplification Test
Departments of Microbiology and Infection Control, University Hospital of North Norway, Norway.
Departments of Microbiology and Infection Control, University Hospital of North Norway, Norway.
Department of Microbiology and Virology, Institute of Medical Biology, Norway.
Departments of Microbiology and Infection Control, University Hospital of North Norway, Norway.
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2012 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 92, no 3, 316-319 p.Article in journal (Refereed) Published
Abstract [en]

Culture is commonly regarded as the gold standard for diagnosis of Neisseria gonorrhoeae. However, nucleic acid amplification tests (NAATs) have rapidly replaced culture for diagnostics in many settings. The aim of the present study was to investigate the appropriate time for test-of-cure (TOC) when NAATs are used for diagnosis of gonorrhoea. In total, 30 patients (28 men and 2 women) provided urethral, cervical, rectal or pharyngeal specimens for TOC. All included patients, except one who did not return for second TOC before day 19, tested negative within 2 weeks after treatment with cefixime 400 mg x 1. Antimicrobial susceptibility testing showed that 68% of the culture-positive strains were resistant to ciprofloxacin. Thus, the recommended empirical treatment with ciprofloxacin in Norway should be changed immediately. TOC can be performed 2 weeks after treatment when NAATs are used for diagnosis of gonorrhoea.

Place, publisher, year, edition, pages
Uppsala: Acta Dermato-Venereologica , 2012. Vol. 92, no 3, 316-319 p.
Keyword [en]
TOC, test-of-cure, N. gonorrhoeae, PCR, NAAT
National Category
Infectious Medicine Clinical Laboratory Medicine Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-58680DOI: 10.2340/00015555-1275ISI: 000305814300024PubMedID: 22286973Scopus ID: 2-s2.0-84859753142OAI: oai:DiVA.org:oru-58680DiVA: diva2:1122201
Note

Funding Agency:

Department of Microbiology at the University Hospital of North Norway, Tromso, Norway

Available from: 2017-07-12 Created: 2017-07-12 Last updated: 2017-09-12Bibliographically approved

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Unemo, Magnus

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