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Pediatric autoimmune neuropsychiatric syndrome (PANS), developmental regression and autism
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-3587-6075
Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden.
2017 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 41, no Suppl., S123-S123 p.Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Introduction: Pediatric autoimmune neuropsychiatric syndrome (PANS) is a term used to describe a clinical picture which includes sudden onset of psychiatric symptoms and a possible autoimmune genesis. The sudden decline in neuropsychiatric functioning as well as the multiple combinations of symptoms may lead to a clinical phenotype similar to that in infantile autism (IA) with regressive features. We are conducting a study with the aim to evaluate a diagnostic test for PANS currently marketed by Moleculera Labs. All patients in Sweden who had taken the test (n = 154) were invited to the study.

Objectives: The aim of the study is to characterize a subgroup of patients with IA within the PANS diagnosis study.

Methods: Participants (n = 53) were examined for psychiatric and somatic symptoms and evaluated for PANS caseness by an experienced psychiatrist. Because the criteria for entering the study was having taken the diagnostic test for PANS, the participants in the study comprise a group with mixed symptoms.

Results: Twelve participants had IA. Eleven of these reported a developmental regression with loss of abilities. Two of the IA patients also fulfill criteria for PANS. Eight of the IA patients had been treated with antibiotics for psychiatric symptoms and 4 reported a positive effect of this treatment. Nine of the patients had elevated test results suggesting possible PANS according to Moleculera Labs.

Conclusions: Very early onset on PANS may be phenotypically similar to IA with regressive features. Further analysis of the immunological attributes of patients with autism with regressive features is warranted.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 41, no Suppl., S123-S123 p.
National Category
Psychiatry
Research subject
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-58969DOI: 10.1016/j.eurpsy.2017.01.1921ISI: 000404952200364OAI: oai:DiVA.org:oru-58969DiVA: diva2:1129532
Available from: 2017-08-04 Created: 2017-08-04 Last updated: 2017-10-18Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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