A Family-Based Study of the Association Between Labor Induction and Offspring Attention-Deficit Hyperactivity Disorder and Low Academic AchievementShow others and affiliations
2017 (English)In: Behavior Genetics, ISSN 0001-8244, E-ISSN 1573-3297, Vol. 47, no 4, p. 383-393Article in journal (Refereed) Published
Abstract [en]
The current study examined associations between labor induction and both (1) offspring attention-deficit hyperactivity disorder (ADHD) diagnosis in a Swedish birth cohort born 1992-2005 (n = 1,085,008) and (2) indices of offspring low academic achievement in a sub-cohort born 1992-1997 (n = 489,196). Associations were examined in the entire sample (i.e., related and unrelated individuals) with adjustment for measured covariates and, in order to account for unmeasured confounders shared within families, within differentially exposed cousins and siblings. We observed an association between labor induction and offspring ADHD diagnosis and low academic achievement in the population. However, these associations were fully attenuated after adjusting for measured covariates and unmeasured factors that cousins and siblings share. The results suggest that observed associations between labor induction and ADHD and low academic achievement may be due to genetic and/or shared environmental factors that influence both mothers' risk of labor induction and offspring neurodevelopment.
Place, publisher, year, edition, pages
Springer, 2017. Vol. 47, no 4, p. 383-393
Keywords [en]
Labor induction, Attention-deficit hyperactivity disorder, Academic achievement, Family studies, Sibling comparison, Cousin comparison
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-58942DOI: 10.1007/s10519-017-9852-4ISI: 000403569500002PubMedID: 28551761Scopus ID: 2-s2.0-85019730858OAI: oai:DiVA.org:oru-58942DiVA, id: diva2:1134383
Note
Funding Agencies:
Indiana Clinical and Translational Sciences Institute: Pediatric Project Development Team
Swedish Research Council through the Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM) 340-2013-5867
National Institute of Health, T32 Grant HD 07475
Institutional Review Board at the Karolinska Institutet
2017-08-182017-08-182017-10-23Bibliographically approved