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Dog Exposure During the First Year of Life and Type 1 Diabetes in Childhood
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Örebro University, School of Medical Sciences. Clinical Epidemiology and Biostatistics.ORCID iD: 0000-0002-3649-2639
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2017 (English)In: JAMA pediatrics, ISSN 2168-6203, E-ISSN 2168-6211, Vol. 171, no 7, 663-669 p.Article in journal (Refereed) Published
Abstract [en]

IMPORTANCE: The association between early exposure to animals and type 1 diabetes in childhood is not clear.

OBJECTIVE: To determine whether exposure to dogs during the first year of life is associated with the development of type 1 diabetes in childhood.

DESIGN, SETTING, AND PARTICIPANTS: A nationwide cohort study utilizing high-quality Swedish national demographic and health registers was conducted. A total of 840 593 children born in Sweden from January 1, 2001, to December 31, 2010, were evaluated. Type 1 diabetes was identified using diagnosis codes from hospitals and dispensed prescriptions of insulin. Cox proportional hazards regression models were used to assess the association between exposure to dogs and risk of type 1 diabetes in childhood. The possible association was further investigated by performing dose-response and breed group-specific analyses. The cohort was followed up until September 30, 2012. Data analysis was conducted from October 15, 2015, to February 8, 2017.

EXPOSURES: Having a parent who was registered as a dog owner during the child's first year of life.

MAIN OUTCOMES AND MEASURES: Childhood-onset type 1 diabetes.

RESULTS: Of the 840 593 children reviewed, 408 272 (48.6%) were girls; mean (SD) age at diagnosis of type 1 diabetes was 5.1 (2.6) years. Dog exposure was identified in 102 035 children (12.1%). Follow-up started at age 1 year, and the children were followed up for as long as 10.7 years (median, 5.5 years). During follow-up, 1999 children developed type 1 diabetes. No association was found between exposure to dogs (adjusted hazard ratio [HR], 1.00; 95% CI, 0.86-1.16) and type 1 diabetes in childhood. The size of the dog (adjusted HR per 10-cm increase in height, 0.96; 95% CI, 0.86-1.06) or number of dogs in the household (1 dog: adjusted HR, 1.07; 95% CI, 0.91-1.26; 2 dogs: 0.79; 95% CI, 0.54-1.15; >= 3 dogs: 0.50; 95% CI, 0.23-1.12; compared with nonexposed children) also was not associated with type 1 diabetes risk. An analysis of children whose parent had type 1 diabetes (210 events) yielded an adjusted HR of 0.71 (95% CI, 0.43-1.17) for dog exposure.

CONCLUSIONS AND RELEVANCE: In a nationwide study, no evidence supporting an association of register-derived measures of dog exposure with childhood type 1 diabetes was identified.

Place, publisher, year, edition, pages
American Medical Association , 2017. Vol. 171, no 7, 663-669 p.
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-58935DOI: 10.1001/jamapediatrics.2017.0585ISI: 000404604400012PubMedID: 28459973Scopus ID: 2-s2.0-85024384320OAI: oai:DiVA.org:oru-58935DiVA: diva2:1134737
Funder
Swedish Research Council, 2015-03477
Note

Funding Agencies:

Diabetesfonden grant  DIA 2014-026

Swedish Initiative for Research on Microdata in the Social and Medical Sciences  80748301  340-2013-5867

Available from: 2017-08-21 Created: 2017-08-21 Last updated: 2017-10-18Bibliographically approved

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CiteExportLink to record
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