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High-dose B-vitamin supplements and risk for age-related cataract: a population-based prospective study of men and women
Division of Nutritional Epidemiology, Institute of Environment al Medicine, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Division of Nutritional Epidemiology, Institute of Environment al Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Ophthalmology, School of Medical Sciences, Örebro University, Örebro, Sweden.
Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Division of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
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2017 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 118, no 2, 154-160 p.Article in journal (Refereed) Published
Abstract [en]

Previous studies that have investigated the association between B-vitamin supplement use and risk for cataract yield conflicting results. The aim of this study was to examine the association between use of high-dose B-vitamin supplements (approximately 10 times recommended daily intake) and risk for age-related cataract in a population-based prospective study of 13 757 women from the Swedish Mammography Cohort and 22 823 men from the Cohort of Swedish Men. Dietary supplement use and potential confounders were assessed using a questionnaire at baseline. Information on cataract diagnosis and extraction was obtained through linkage to registers. During the follow-up period between January 1998 and December 2011, we identified 8395 cataract cases (3851 for women and 4544 for men). The use of B vitamins plus other supplements and B vitamins only was associated with 9 % (95 % CI 2, 17) and 27 % (95 % CI 12, 43) increased risk for cataract, respectively. The hazard ratios for use of B vitamins only and risk for cataract stratified by different age groups were as follows: <60 years: 1·88 (95 % CI 1·47, 2·39); 60-69 years: 1·21 (95 % CI 0·96, 1·53); and ≥70 years: 1·09 (95 % CI 0·91, 1·31) (P interaction=0·002). Our results suggest that the use of high-dose B-vitamin supplements was associated with an increased risk for cataract. This association might be confined to younger participants.

Place, publisher, year, edition, pages
Cambridge University Press, 2017. Vol. 118, no 2, 154-160 p.
Keyword [en]
B-vitamin supplements: Cataracts: Prospective cohort studies: Nutritional epidemiology
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-59243DOI: 10.1017/S0007114517001994ISI: 000409508200007PubMedID: 28820082Scopus ID: 2-s2.0-85028034737OAI: oai:DiVA.org:oru-59243DiVA: diva2:1135286
Funder
Swedish Research Council, 2008-5947Forte, Swedish Research Council for Health, Working Life and Welfare, 2010- 1064
Available from: 2017-08-22 Created: 2017-08-22 Last updated: 2017-09-21Bibliographically approved

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Lindblad, Birgitta Ejdervik
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