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Increased risk of cataract among 28,000 patients with celiac disease
Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Eugeniahemmet, Stockholm, Sweden.
St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden.
Department of Ophthalmology, Sundsvall Hospital, Sundsvall, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Clinical Epidemiology Unit, Department of Medicine, Karolinska University Hospital, Eugeniahemmet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-1024-5602
2011 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 174, no 2, 195-202 p.Article in journal (Refereed) Published
Abstract [en]

Vitamin deficiencies are prevalent in celiac disease (CD) and are associated with cataract formation, but it is unknown whether persons with CD are at increased risk of cataract. The authors' objective in this population-based cohort study was to determine the risk of cataract among persons with biopsy-verified CD. Data on CD were collected from reports on small intestinal biopsies performed between July 1969 and February 2008 in the 28 regional pathology departments in Sweden. The authors identified 28,756 persons with CD (villous atrophy, Marsh pathology stage 3). For each person with CD, Statistics Sweden selected up to 5 controls matched for age and sex from the Total Population Register. Data on cataract were obtained from the Swedish National Hospital Discharge Register and the National Day-Surgery Register. Cox regression analysis was used to estimate the risk of cataract. During a median follow-up period of 9 years, the authors identified 1,159 cataracts among persons with CD (909 were expected) (hazard ratio = 1.28, 95% confidence interval: 1.19, 1.36). The absolute risk of cataract was 397/100,000 person-years in CD, with an excess risk of 86/100,000 person-years. In conclusion, this study found an increased risk of developing cataract in patients with CD.

Place, publisher, year, edition, pages
Oxford University Press, 2011. Vol. 174, no 2, 195-202 p.
Keyword [en]
autoimmunity; cataract; celiac disease; cohort studies; eye
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-59244DOI: 10.1093/aje/kwr069ISI: 000292778600009PubMedID: 21624959Scopus ID: 2-s2.0-79960516342OAI: oai:DiVA.org:oru-59244DiVA: diva2:1135291
Funder
Swedish Society of MedicineSven Jerring Foundation
Note

Funding Agencies:

Swedish Research Council-Medicine  522-2A09-195 

Örebro Society of Medicine  

Karolinska Institutet  

Clas Groschinsky Foundation  

Juhlin Foundation  

Majblomman Foundation   U

ppsala-Örebro Regional Research Council  

Swedish Celiac Society  

Örebro University Hospital 

Available from: 2017-08-22 Created: 2017-08-22 Last updated: 2017-10-18Bibliographically approved

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