Increased risk of cataract among 28,000 patients with celiac disease
2011 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 174, no 2, p. 195-202Article in journal (Refereed) Published
Abstract [en]
Vitamin deficiencies are prevalent in celiac disease (CD) and are associated with cataract formation, but it is unknown whether persons with CD are at increased risk of cataract. The authors' objective in this population-based cohort study was to determine the risk of cataract among persons with biopsy-verified CD. Data on CD were collected from reports on small intestinal biopsies performed between July 1969 and February 2008 in the 28 regional pathology departments in Sweden. The authors identified 28,756 persons with CD (villous atrophy, Marsh pathology stage 3). For each person with CD, Statistics Sweden selected up to 5 controls matched for age and sex from the Total Population Register. Data on cataract were obtained from the Swedish National Hospital Discharge Register and the National Day-Surgery Register. Cox regression analysis was used to estimate the risk of cataract. During a median follow-up period of 9 years, the authors identified 1,159 cataracts among persons with CD (909 were expected) (hazard ratio = 1.28, 95% confidence interval: 1.19, 1.36). The absolute risk of cataract was 397/100,000 person-years in CD, with an excess risk of 86/100,000 person-years. In conclusion, this study found an increased risk of developing cataract in patients with CD.
Place, publisher, year, edition, pages
Oxford University Press, 2011. Vol. 174, no 2, p. 195-202
Keywords [en]
autoimmunity; cataract; celiac disease; cohort studies; eye
National Category
Public Health, Global Health and Social Medicine
Identifiers
URN: urn:nbn:se:oru:diva-59244DOI: 10.1093/aje/kwr069ISI: 000292778600009PubMedID: 21624959Scopus ID: 2-s2.0-79960516342OAI: oai:DiVA.org:oru-59244DiVA, id: diva2:1135291
Funder
Swedish Society of MedicineSven Jerring Foundation
Note
Funding Agencies:
Swedish Research Council-Medicine 522-2A09-195
Örebro Society of Medicine
Karolinska Institutet
Clas Groschinsky Foundation
Juhlin Foundation
Majblomman Foundation U
ppsala-Örebro Regional Research Council
Swedish Celiac Society
Örebro University Hospital
2017-08-222017-08-222025-02-21Bibliographically approved