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Vitamin C supplements and the risk of age-related cataract: a population-based prospective cohort study in women
Divisions of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Divisions of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Ophthalmology, Sundsvall Hospital, Sundsvall, Sweden.
Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Divisions of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
2010 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 91, no 2, 487-93 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Experimental animal studies have shown adverse effects of high-dose vitamin C supplements on age-related cataract.

OBJECTIVE: We examined whether vitamin C supplements (approximately 1000 mg) and multivitamins containing vitamin C (approximately 60 mg) are associated with the incidence of age-related cataract extraction in a population-based, prospective cohort of women.

DESIGN: Our study included 24,593 women aged 49-83 y from the Swedish Mammography Cohort (follow-up from September 1997 to October 2005). We collected information on dietary supplement use and lifestyle factors with the use of a self-administrated questionnaire. Cataract extraction cases were identified by linkage to the cataract extraction registers in the geographical study area.

RESULTS: During the 8.2 y of follow-up (184,698 person-years), we identified 2497 cataract extraction cases. The multivariable hazard ratio (HR) for vitamin C supplement users compared with that for nonusers was 1.25 (95% CI: 1.05, 1.50). The HR for the duration of >10 y of use before baseline was 1.46 (95% CI: 0.93, 2.31). The HR for the use of multivitamins containing vitamin C was 1.09 (95% CI: 0.94, 1.25). Among women aged > or = 65 y, vitamin C supplement use increased the risk of cataract by 38% (95% CI: 12%, 69%). Vitamin C use among hormone replacement therapy users compared with that among nonusers of supplements or of hormone replacement therapy was associated with a 56% increased risk of cataract (95% CI: 20%, 102%). Vitamin C use among corticosteroid users compared with that among nonusers of supplements and corticosteroids was associated with an HR of 1.97 (95% CI: 1.35, 2.88).

CONCLUSION: Our results indicate that the use of vitamin C supplements may be associated with higher risk of age-related cataract among women.

Place, publisher, year, edition, pages
American Society for Nutrition , 2010. Vol. 91, no 2, 487-93 p.
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-59245DOI: 10.3945/ajcn.2009.28528ISI: 000273947500026PubMedID: 19923367Scopus ID: 2-s2.0-75649152844OAI: oai:DiVA.org:oru-59245DiVA: diva2:1135292
Available from: 2017-08-22 Created: 2017-08-22 Last updated: 2017-10-18Bibliographically approved

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