Vitamin C supplements and the risk of age-related cataract: a population-based prospective cohort study in women
2010 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 91, no 2, p. 487-93Article in journal (Refereed) Published
Abstract [en]
BACKGROUND: Experimental animal studies have shown adverse effects of high-dose vitamin C supplements on age-related cataract.
OBJECTIVE: We examined whether vitamin C supplements (approximately 1000 mg) and multivitamins containing vitamin C (approximately 60 mg) are associated with the incidence of age-related cataract extraction in a population-based, prospective cohort of women.
DESIGN: Our study included 24,593 women aged 49-83 y from the Swedish Mammography Cohort (follow-up from September 1997 to October 2005). We collected information on dietary supplement use and lifestyle factors with the use of a self-administrated questionnaire. Cataract extraction cases were identified by linkage to the cataract extraction registers in the geographical study area.
RESULTS: During the 8.2 y of follow-up (184,698 person-years), we identified 2497 cataract extraction cases. The multivariable hazard ratio (HR) for vitamin C supplement users compared with that for nonusers was 1.25 (95% CI: 1.05, 1.50). The HR for the duration of >10 y of use before baseline was 1.46 (95% CI: 0.93, 2.31). The HR for the use of multivitamins containing vitamin C was 1.09 (95% CI: 0.94, 1.25). Among women aged > or = 65 y, vitamin C supplement use increased the risk of cataract by 38% (95% CI: 12%, 69%). Vitamin C use among hormone replacement therapy users compared with that among nonusers of supplements or of hormone replacement therapy was associated with a 56% increased risk of cataract (95% CI: 20%, 102%). Vitamin C use among corticosteroid users compared with that among nonusers of supplements and corticosteroids was associated with an HR of 1.97 (95% CI: 1.35, 2.88).
CONCLUSION: Our results indicate that the use of vitamin C supplements may be associated with higher risk of age-related cataract among women.
Place, publisher, year, edition, pages
American Society for Nutrition , 2010. Vol. 91, no 2, p. 487-93
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-59245DOI: 10.3945/ajcn.2009.28528ISI: 000273947500026PubMedID: 19923367Scopus ID: 2-s2.0-75649152844OAI: oai:DiVA.org:oru-59245DiVA, id: diva2:1135292
2017-08-222017-08-222025-02-11Bibliographically approved