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Metabolic syndrome components in relation to risk of cataract extraction: a prospective cohort study of women
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Ophthalmology, Sundsvall Hospital, Sundsvall, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Stockholm Eye Clinic, H. M. Queen Sophia Hospital, Stockholm, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
2008 (English)In: Ophthalmology (Rochester, Minn.), ISSN 0161-6420, E-ISSN 1549-4713, Vol. 115, no 10, 1687-1692 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate the association between metabolic syndrome and some of its components with the incidence of cataract extraction.

DESIGN: Population-based prospective cohort study.

PARTICIPANTS: A total of 35,369 women, participating in the Swedish Mammography Cohort, aged 49 to 83 years, who completed a self-administered questionnaire about anthropometric measurements and lifestyle factors in 1997.

METHODS: The women were followed from September of 1997 to October of 2005. The cohort was matched with registers of cataract extraction in the study area.

MAIN OUTCOME MEASURES: Incident surgical extraction of age-related cataract.

RESULTS: We identified 4508 incident cases of cataract extractions during 98 months of follow-up. In multivariate analysis, women with a waist circumference >or=80 cm had an 8% increased risk of cataract extraction (rate ratio [RR], 1.08; 95% confidence interval [CI], 0.99-1.17). Women with diabetes had a 43% increased risk of cataract extraction (RR, 1.43; 95% CI, 1.10-1.86), and hypertension was associated with a 12% increased risk (RR, 1.12; 95% CI, 0.99-1.26). Women with all 3 components of the metabolic syndrome (waist >or=80 cm, diabetes, and hypertension) had a 68% increased risk of cataract extraction (RR, 1.68; 95% CI, 1.40-2.02) compared with women without any of these components. Among women aged less than 65 years at baseline with all 3 components of metabolic syndrome, the risk of cataract extraction was approximately 3-fold more (RR, 2.80; CI, 1.94-4.03).

CONCLUSIONS: Metabolic syndrome and its components, abdominal adiposity, diabetes, and hypertension, seem to be associated with an increased risk for cataract extraction, especially among women aged less than 65 years.

Place, publisher, year, edition, pages
Elsevier, 2008. Vol. 115, no 10, 1687-1692 p.
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:oru:diva-59247DOI: 10.1016/j.ophtha.2008.04.004ISI: 000259852200007PubMedID: 18538408Scopus ID: 2-s2.0-52949142734OAI: oai:DiVA.org:oru-59247DiVA: diva2:1135294
Note

Funding Agencies:

Swedish Research Council/Medicine, Stockholm, Sweden  

Swedish Council for Working Life and Social Research, Stockholm, Sweden  

Crown Princess Margaret's Foundation, Stockholm, Sweden  

Carmen and Bertil Regner Foundation, Stockholm, Sweden  

Synfrämjandet in Stockholm, Sweden  

Västernorrland County Council, Sundsvall, Sweden 

Available from: 2017-08-22 Created: 2017-08-22 Last updated: 2017-10-18Bibliographically approved

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Lindblad, Birgitta Ejdervik

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