oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
VTT Technical Research Centre of Finland, Espoo, Finland.ORCID iD: 0000-0002-2856-9165
Department of Pediatrics, University of Turku, Turku, Finland.
VTT Technical Research Centre of Finland, Espoo, Finland.
Department of Pediatrics, University of Turku, Turku, Finland.
Show others and affiliations
2008 (English)In: Journal of Experimental Medicine, ISSN 0022-1007, E-ISSN 1540-9538, Vol. 205, no 13, 2975-84 p.Article in journal (Refereed) Published
Abstract [en]

The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward beta cell failure, and factors determining time of presentation of clinical diabetes are poorly understood. We investigated changes in the serum metabolome prospectively in children who later progressed to type 1 diabetes. Serum metabolite profiles were compared between sample series drawn from 56 children who progressed to type 1 diabetes and 73 controls who remained nondiabetic and permanently autoantibody negative. Individuals who developed diabetes had reduced serum levels of succinic acid and phosphatidylcholine (PC) at birth, reduced levels of triglycerides and antioxidant ether phospholipids throughout the follow up, and increased levels of proinflammatory lysoPCs several months before seroconversion to autoantibody positivity. The lipid changes were not attributable to HLA-associated genetic risk. The appearance of insulin and glutamic acid decarboxylase autoantibodies was preceded by diminished ketoleucine and elevated glutamic acid. The metabolic profile was partially normalized after the seroconversion. Autoimmunity may thus be a relatively late response to the early metabolic disturbances. Recognition of these preautoimmune alterations may aid in studies of disease pathogenesis and may open a time window for novel type 1 diabetes prevention strategies.

Place, publisher, year, edition, pages
New York, USA: Rockefeller University Press, 2008. Vol. 205, no 13, 2975-84 p.
National Category
Medical and Health Sciences Immunology
Identifiers
URN: urn:nbn:se:oru:diva-59350DOI: 10.1084/jem.20081800ISI: 000266428700005PubMedID: 19075291Scopus ID: 2-s2.0-59649105735OAI: oai:DiVA.org:oru-59350DiVA: diva2:1135855
Note

Funding Agencies:

Juvenile Diabetes Research Foundation International, Projektnr. 4-1999-731, 4-2001-435 

European Community, Projektnr. HEALTH-F2-2008-202013

Academy of Finland

Sigrid Juselius Foundation

Paivikki and Sakari Sohlberg Foundation

Signe and Ane Gyllenberg Foundation

Diabetes Research Foundation, Finland

Special Federal Funds to the Turku, Oulu

Tampere University Hospitals

Available from: 2017-08-24 Created: 2017-08-24 Last updated: 2017-09-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Oresic, Matej
In the same journal
Journal of Experimental Medicine
Medical and Health SciencesImmunology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 12 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf