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Modeling strategies to study metabolic pathways in progression to type 1 diabetes: Challenges and opportunities
Steno Diabetes Center A/S, Gentofte, Denmark.
Steno Diabetes Center A/S, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.ORCID iD: 0000-0002-2856-9165
2016 (English)In: Archives of Biochemistry and Biophysics, ISSN 0003-9861, E-ISSN 1096-0384, Vol. 589, p. 131-7Article, review/survey (Refereed) Published
Abstract [en]

Seroconversion to islet autoimmunity is preceded by metabolic disturbances in children who later progress to overt type 1 diabetes (T1D). The underlying metabolic pathways and the interaction of metabolic and immune system factors involved in progression to the disease are however poorly understood. There is a clear need for mathematical models which capture the temporal and spatial complexity of early pathogenesis of T1D. Here we review the early attempts to model the development of islet autoimmunity and T1D, including the models which emphasize the potential beneficial role of autoimmune response in specific circumstances, such as to 'correct' for the early metabolic disturbances. We also highlight the genome-scale metabolic modeling as a promising new avenue to study metabolism and its interactions with the immune system in T1D.

Place, publisher, year, edition, pages
Maryland Heights, MO, USA: Academic Press, 2016. Vol. 589, p. 131-7
Keywords [en]
Autoimmunity, Lipidomics, Metabolic modeling, Metabolomics, Type 1 diabetes
National Category
Medical and Health Sciences Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-59363DOI: 10.1016/j.abb.2015.08.011ISI: 000368321600013PubMedID: 26314918Scopus ID: 2-s2.0-84951569281OAI: oai:DiVA.org:oru-59363DiVA, id: diva2:1136089
Note

Funding Agencies:

Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research, Projektnr. 250114

Juvenile Diabetes Research Foundation, Projektnr. 2-SRA-2014-159-Q-R

Available from: 2017-08-25 Created: 2017-08-25 Last updated: 2017-09-21Bibliographically approved

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Oresic, Matej

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CiteExportLink to record
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