Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responsesComputational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland.
VTT Technical Research Centre of Finland, Espoo, Finland.
Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland.
Genomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland; Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland.
Department of Clinical Physiology, University of Tampere, Tampere University Hospital, Tampere, Finland.
Department of Medicine, University of Turku, Turku, Finland; Division of Medicine, Turku University Hospital, Turku, Finland.
Brain and Work Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland.
Brain and Work Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland; Agora Center, University of Jyväskylä, Jyväskylä, Finland.
Minerva Foundation Institute for Medical Research, Helsinki, Finland; Institute of Biomedicine, Anatomy, University of Helsinki, Helsinki, Finland.
Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland.
Genomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland.
Genomics and Biomarkers Unit, Institute for Molecular Medicine FIMM, National Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, School of Medicine, Tampere, Finland.
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Oulu University Hospital, Oulu, Finland; Computational Medicine, School of Social and Community Medicine, Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.
Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
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2016 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 6, article id 24828
Article in journal (Refereed) Published
Abstract [en]
Sleep loss and insufficient sleep are risk factors for cardiometabolic diseases, but data on how insufficient sleep contributes to these diseases are scarce. These questions were addressed using two approaches: an experimental, partial sleep restriction study (14 cases and 7 control subjects) with objective verification of sleep amount, and two independent epidemiological cohorts (altogether 2739 individuals) with questions of sleep insufficiency. In both approaches, blood transcriptome and serum metabolome were analysed. Sleep loss decreased the expression of genes encoding cholesterol transporters and increased expression in pathways involved in inflammatory responses in both paradigms. Metabolomic analyses revealed lower circulating large HDL in the population cohorts among subjects reporting insufficient sleep, while circulating LDL decreased in the experimental sleep restriction study. These findings suggest that prolonged sleep deprivation modifies inflammatory and cholesterol pathways at the level of gene expression and serum lipoproteins, inducing changes toward potentially higher risk for cardiometabolic diseases.
Place, publisher, year, edition, pages
Nature Publishing Group, 2016. Vol. 6, article id 24828
National Category
Other Clinical Medicine
Identifiers
URN: urn:nbn:se:oru:diva-59377DOI: 10.1038/srep24828ISI: 000374588600001PubMedID: 27102866Scopus ID: 2-s2.0-84964253389OAI: oai:DiVA.org:oru-59377DiVA, id: diva2:1136160
Note
Funding Agencies:
EU LSHM-CT-2005-518189 QLK6-CT-2000-00499
Finska Läkaresällskapet
Finnish Work Environment Fund
Yrjo Jahnsson Foundation
Orion Research Foundation
Jenny and Antti Wihuri Foundation
Finnish Foundation for Cardiovascular Research
Liv och Hälsa Foundation
Magnus Ehrnrooth Foundation
Diabetes Research Foundation
Sigrid Juselius Foundation
Helsinki University Central Hospital research funds TYH6254
Carlos III Health Institute of the Spanish Ministry of Health
Academy of Finland 118065 138201 283045 139635 137870 257545 250114 137575 134309 126925 121584 124282 129378 117797 41071
Academy of Finland
TEKES - the Finnish Funding Agency for Technology and Innovation
Novo Nordisk Foundation
Finnish Diabetes Research Foundation
University of Oulu, Finland
British Heart Foundation
Welcome Trust
Medical Research Council, UK
Social Insurance Institution of Finland
Kuopio, Tampere and Turku University Hospital Medical Funds
Juho Vainio Foundation
Paavo Nurmi Foundation
Finnish Foundation of Cardiovascular Research
Finnish Cultural Foundation
Tampere Tuberculosis Foundation
Emil Aaltonen Foundation
2017-08-252017-08-252022-09-15Bibliographically approved