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Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study
Department of Pediatric Research, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway; Hormone Laboratory, Department of Medical Biochemistry, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway.
Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
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2017 (English)In: Pediatric Diabetes, ISSN 1399-543X, E-ISSN 1399-5448, Vol. 18, no 2, 111-119 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: The aim of this study was to investigate the longitudinal plasma metabolic profiles in healthy infants and the potential association with breastfeeding duration and islet autoantibodies predictive of type 1 diabetes.

METHOD: Up to four longitudinal plasma samples from age 3 months from case children who developed islet autoimmunity (n = 29) and autoantibody-negative control children (n = 29) with the HLA DR4-DQ8/DR3-DQ2 genotype were analyzed using two-dimensional gas chromatography coupled to a time-of-flight mass spectrometer for detection of small polar metabolites.

RESULTS: Plasma metabolite levels were found to depend strongly on age, with fold changes varying up to 50% from age 3 to 24 months (p < 0.001 after correction for multiple testing). Tyrosine levels tended to be lower in case children, but this was not significant after correction for multiple testing. Ornithine levels were lower in case children compared with the controls at the time of seroconversion, but the difference was not statistically significant after correcting for multiple testing. Breastfeeding for at least 3 months as compared with shorter duration was associated with higher plasma levels of isoleucine, and lower levels of methionine and 3,4-dihydroxybutyric acid at 3 months of age.

CONCLUSIONS: Plasma levels of several small, polar metabolites changed with age during early childhood, independent of later islet autoimmunity status and sex. Breastfeeding was associated with higher levels of branched-chain amino acids, and lower levels of methionine and 3,4-dihydroxybutyric acid.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2017. Vol. 18, no 2, 111-119 p.
Keyword [en]
autoimmunity, breast feeding, diabetes mellitus, type 1, metabolome, metabolomics
National Category
Endocrinology and Diabetes Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-59387DOI: 10.1111/pedi.12360ISI: 000393919500004PubMedID: 26791677Scopus ID: 2-s2.0-84955499390OAI: oai:DiVA.org:oru-59387DiVA: diva2:1136174
Note

Funding Agency:

Research Council of Norway  214191  166515/V50

Available from: 2017-08-25 Created: 2017-08-25 Last updated: 2017-09-08Bibliographically approved

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Orešič, MatejHyötyläinen, Tuulia

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