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Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
VTT Technical Research Centre of Finland Ltd., Espoo, Finland.
VTT Technical Research Centre of Finland Ltd., Espoo, Finland.
University of Helsinki and Helsinki University Hospital, Psychiatry, Helsinki, Finland.
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2017 (English)In: Schizophrenia Research, ISSN 0920-9964, E-ISSN 1573-2509Article in journal (Refereed) In press
Abstract [en]

The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences were associated with response after up to 12months of treatment. Numbers of Lactobacillus group bacteria were elevated in FEP-patients and significantly correlated with severity along different symptom domains. A subgroup of FEP patients with the strongest microbiota differences also showed poorer response after up to 12months of treatment. The present findings support the involvement of microbiota alterations in psychotic illness and may provide the basis for exploring the benefit of their modulation on treatment response and remission.

Place, publisher, year, edition, pages
Amsterdam, Netherlands: Elsevier, 2017.
Keywords [en]
Microbiome, Psychosis, Response, Schizophrenia
National Category
Medical and Health Sciences Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-59391DOI: 10.1016/j.schres.2017.04.017PubMedID: 28442250Scopus ID: 2-s2.0-85018792632OAI: oai:DiVA.org:oru-59391DiVA, id: diva2:1136177
Available from: 2017-08-25 Created: 2017-08-25 Last updated: 2018-01-04Bibliographically approved

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Oresic, Matej

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