oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Common shared genetic variation behind decreased risk of breast cancer in celiac disease
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Human Genetics, Genome Institute of Singapore, Singapore, Singapore.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0003-1024-5602
Show others and affiliations
2017 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, article id 5942Article in journal (Refereed) Published
Abstract [en]

There is epidemiologic evidence showing that women with celiac disease have reduced risk of later developing breast cancer, however, the etiology of this association is unclear. Here, we assess the extent of genetic overlap between the two diseases. Through analyses of summary statistics on densely genotyped immunogenic regions, we show a significant genetic correlation (r = -0.17, s.e. 0.05, P < 0.001) and overlap (Ppermuted < 0.001) between celiac disease and breast cancer. Using individuallevel genotype data from a Swedish cohort, we find higher genetic susceptibility to celiac disease summarized by polygenic risk scores to be associated with lower breast cancer risk (ORper-SD, 0.94, 95% CI 0.91 to 0.98). Common single nucleotide polymorphisms between the two diseases, with low P-values (P-CD < 1.00E-05, P-BC <= 0.05), mapped onto genes enriched for immunoregulatory and apoptotic processes. Our results suggest that the link between breast cancer and celiac disease is due to a shared polygenic variation of immune related regions, uncovering pathways which might be important for their development.

Place, publisher, year, edition, pages
Nature Publishing Group, 2017. Vol. 7, article id 5942
National Category
Medical Genetics Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-59308DOI: 10.1038/s41598-017-06287-9ISI: 000405895900007PubMedID: 28725034Scopus ID: 2-s2.0-85025116632OAI: oai:DiVA.org:oru-59308DiVA, id: diva2:1136193
Funder
Swedish Research Council, 2014-2271Swedish Cancer Society, CAN 2016/684
Note

Funding Agencies:

Cancer Society in Stockholm  141092 

Ollie and Elof Ericsson Foundation  

Åke Wiberg Foundation  M16-0019 

Singapore National Research Foundation Fellowship  

Cancer Research UK  C1287/A16563  C1287/A10118  C1287/A 10710  C12292/A11174  C1281/A12014  C5047/A8384  C5047/A15007  C5047/A10692  C8197/A16565 

European Community's Seventh Framework Programme  223175  HEALTH-F2-2009-223175  223175 (HEALTH-F2-2009-223175) 

National Institutes of Health  CA128978 

Post-Cancer GWAS initiative  1U19 CA148537  1U19 CA148065  1U19 CA148112 

Department of Defence  W81XWH-10-1-0341 

Canadian Institutes of Health Research (CIHR)  

Komen Foundation for the Cure  

Breast Cancer Research Foundation  

Ovarian Cancer Research Fund 

Available from: 2017-08-25 Created: 2017-08-25 Last updated: 2018-01-13Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Ludvigsson, Jonas F.

Search in DiVA

By author/editor
Ludvigsson, Jonas F.
By organisation
School of Medical SciencesÖrebro University Hospital
In the same journal
Scientific Reports
Medical GeneticsCancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 84 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf